Neuropathic pain changes the output of rat lamina I spino-parabrachial neurons

被引：1

作者：

Krotov, Volodymyr ^{[1
,2
]}

Agashkov, Kirill ^{[1
]}

Romanenko, Sergii ^{[1
]}

Koroid, Kostiantyn ^{[1
]}

Krasniakova, Marharyta ^{[1
]}

Belan, Pavel ^{[2
,3
]}

Voitenko, Nana ^{[3
,4
]}

机构：

[1] NASU, Bogomoletz Inst Physiol, Dept Sensory Signaling, Kiev, Ukraine

[2] Kyiv, Bogomoletz Inst Physiol, Dept Mol Biophys, Kiev, Ukraine

[3] NASU, Kyiv Acad Univ, Kiev, Ukraine

[4] Dobrobut Acad Med Sch, Kiev, Ukraine

来源：

BBA ADVANCES | 2023年 / 3卷

关键词：

Neuropathic pain; Allodynia; Hyperalgesia; Spontaneous pain; Nociception; Spared nerve injury; Spinal cord; Lamina I; Spino-parabrachial projection neurons; Action potential; SPARED NERVE INJURY; SPINOPARABRACHIAL NEURONS; ANIMAL-MODEL;

D O I：

10.1016/j.bbadva.2023.100081

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

center dot Spared nerve injury (SNI) altered the action potential (AP) output of lamina I spino-parabrachial neurons (SPNs) without affecting their resting potential or membrane resistance. center dot In one-third of SPNs, high -threshold dorsal root stimulation elicited persistent AP firing which was never observed in cells from na & iuml;ve animals. center dot 38% of SPNs from SNI rats showed spontaneous persistent AP firing. center dot After SNI lowand high -output SPNs were no longer nociceptive-specific as part of them responded with APs to low -threshold stimulation. center dot These SNI-induced changes of SPN output might represent cellular mechanisms for neuropathy-associated allodynia, hyperalgesia, and spontaneous pain.

引用

页数：4

共 15 条

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