Abietane Diterpenoids from the Bark of Cryptomeria japonica and Their Antifungal Activities against Wood Decay Fungi

被引:1
作者
Chang, Chi-, I [1 ,2 ]
Chen, Cheng-Chi [3 ]
Wang, Sheng-Yang [4 ,5 ]
Kuo, Yueh-Hsiung [6 ,7 ,8 ]
机构
[1] Natl Pingtung Univ Sci & Technol, Dept Biol Sci & Technol, Pingtung 912, Taiwan
[2] Taipei Med Univ Hosp, Tradit Herbal Med Res Ctr, Taipei 110, Taiwan
[3] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan
[4] Natl Chung Hsing Univ, Dept Forestry, Taichung 402, Taiwan
[5] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan
[6] China Med Univ, Coll Pharm, Dept Chinese Pharmaceut Sci & Chinese Med Resource, Taichung 404, Taiwan
[7] Asia Univ, Dept Biotechnol, Taichung 413, Taiwan
[8] China Med Univ, Chinese Med Res Ctr, Taichung 404, Taiwan
来源
PLANTS-BASEL | 2024年 / 13卷 / 09期
关键词
Cupressaceae; Cryptomeria japonica; bark; abietane; antifungal; JAPANESE CEDAR; ESSENTIAL OIL; TERPENOIDS; LEAVES; SESQUITERPENES; COMPONENTS; ANTIFEEDANTS; CONSTITUENTS; HEARTWOOD; EXTRACTS;
D O I
10.3390/plants13091197
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Phytochemical investigation of the bark of Cryptomeria japonica led to the isolation of five new abietane diterpenoids, 5-epi-12-hydroxy-6-nor-5,6-secoabieta-8,11,13-trien-7,5-olide (1), 12-hydroxy-6 beta-methoxy-6,7-secoabieta-8,11,13-trien-7,6-olide (2), 6 beta,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (4), 5,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (5), and 5 alpha,8-epoxy-12-hydroxy-7,8-secoabieta-8,11,13-trien-7-al (6), together with one known abietane diterpenoid, obtuanhydride (3). Their structures were elucidated by analysis of spectroscopic data and comparison with the spectral data of known analogs. At the concentration of 100 mu g/mL, compounds 4, 5, and 6 inhibited antifungal activities against wood decay fungi activity by 18.7, 37.2, and 46.7%, respectively.
引用
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页数:9
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