Whole blood multiplex measurements using electrochemical aptamer-based biosensors

被引：1

作者：

d'Astous, elodie V. ^{[1
]}

Dauphin-Ducharme, Philippe ^{[1
]}

机构：

[1] Univ Sherbrooke, Dept Chim, 2500 boul Univ, Sherbrooke, PQ J1K 2R1, Canada

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 50期

基金：

加拿大自然科学与工程研究理事会;

关键词：

COCAINE-BINDING APTAMER; HIGH-DOSE METHOTREXATE; MOLECULAR MEASUREMENTS; PHARMACOKINETICS; MECHANISM; CHILDREN;

D O I：

10.1039/d4cc01452a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Simultaneous measurements of various molecules ("multiplex") using electrochemical biosensors typically require multiple electrode implementations, which for neonates, hemophiliacs, etc. is problematic. Here, we introduce the oxazine ATTO 700 into electrochemical aptamer-based biosensors to achieve "true" multiplex, continuous and real-time measurements of two different molecules in undiluted whole blood using a single electrode. Simultaneous measurements of various molecules ("multiplex") using electrochemical biosensors typically require multiple electrode implementation, which for neonates, hemophiliacs, etc. is problematic.

引用

页码：6419 / 6422

页数：4

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