Recent Advances in Immune Regulation by Targeting Dendritic Cells using Small Interfering RNAs

被引：2
作者：
Shahverdi, Mahshid [1 ]
Alamdari-Palangi, Vahab [2 ]
Alipour, Shiva [3 ,4 ]
Jolfayi, Amir Ghaffari [5 ]
Masoumi, Javad [3 ]
Aghebati-Maleki, Leili [3 ]
Rostamlou, Arman [6 ]
Baradaran, Behzad [3 ]
机构：
[1] Arak Univ Med Sci, Dept Med Biotechnol, Arak, Iran
[2] Shiraz Univ Med Sci, Sch Adv Med Sci & Technol, Dept Mol Med, Shiraz, Iran
[3] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran
[4] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran
[5] Iran Univ Med Sci, Cardiovasc Res Ctr, Rajaie Cardiovasc Med & Res Ctr, Tehran, Iran
[6] Univ EGE, Fac Med, Dept Med Biol, Izmir, Turkiye
来源：
CURRENT MOLECULAR MEDICINE | 2024年
关键词：
Dendritic cell; delivery systems; immunotherapy; small interfering RNA; targeted immunomodulation; genes' expression; SIRNA DELIVERY; TUMOR-ANTIGEN; VACCINE POTENCY; T-CELLS; POLYMERIC MICELLES; CANCER; GENE; INDUCTION; INTERLEUKIN-10; RECEPTOR;
D O I：
10.2174/0115665240303370240530120450
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Gene silencing through RNA interference (RNAi) technology has provided forceful therapeutic modalities to specific knockdown of the genes' expression related to diseases. Small interfering RNAs (siRNAs) can start a process that specifically degrades and silences the expression of cognate mRNAs. These RNA interference processes could effectively adjust many biological processes, including immune responses. Dendritic cells (DCs) are specialist antigen-presenting cells with potent functions in regulating innate and adaptive immunity. SiRNAs performed vital roles in coordinating immune processes mediated by DCs. This review describes the findings that shed light on the significance of siRNAs in DC immune regulation and highlight their potential applications for improving DC-based immunotherapies
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页数：18
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