Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment

被引：1

作者：

Wisialowski, Todd A. ^{[1
,10
]}

Ether, Nick ^{[2
]}

Foley, Michael ^{[3
]}

Kleiman, Robert ^{[4
]}

Koshman, Yevgeniya ^{[3
]}

Leishman, Derek ^{[5
]}

Martel, Eric ^{[6
]}

Nichols, Jill, V ^{[7
]}

Popp, Julia ^{[7
]}

Rajamani, Sridharan ^{[8
]}

Riley, Steve ^{[1
]}

Rossman, Eric I. ^{[9
]}

Vargas, Hugo M. ^{[2
]}

机构：

[1] Pfizer, Groton, CT USA

[2] Amgen Inc, Thousand Oaks, CA USA

[3] AbbVie, N Chicago, IL USA

[4] Clario, Philadelphia, PA USA

[5] Eli Lilly & Co, Indianapolis, IN USA

[6] Boehringer Ingelheim Pharm GmbH & Co KG, Biberach An Der Riss, Germany

[7] LabCorp, Madison, WI USA

[8] Johnson & Johnson Innovat Med, San Diego, CA USA

[9] GSK, Collegeville, PA USA

[10] Pfizer Res & Dev, Drugs Safety Res & Dev, Groton, CT 06340 USA

来源：

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS | 2024年 / 128卷

关键词：

Canine; Cardiovascular; Concentration-response modeling; ICH E14/S7BQ&As; In vivo; Moxifloxacin; Nonhuman primate; QTc prolongation; Safety pharmacology; Telemetry; MOXIFLOXACIN; PROLONGATION;

D O I：

10.1016/j.vascn.2024.107515

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页数：7

共 21 条

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