SARS-CoV-2 Spike-Derived Peptides Presented by HLA Molecules

被引：6
作者：
Nguyen, Andrea T. [1 ,2 ]
Szeto, Christopher [1 ,2 ]
Jayasinghe, Dhilshan [1 ,2 ]
Lobos, Christian A. [1 ,2 ]
Halim, Hanim [1 ]
Chatzileontiadou, Demetra S. M. [1 ,2 ]
Grant, Emma J. [1 ,2 ]
Gras, Stephanie [1 ,2 ]
机构：
[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia
[2] La Trobe Univ, La Trobe Inst Mol Sci, Dept Biochem & Genet, Melbourne, Vic 3086, Australia
来源：
BIOPHYSICA | 2021年 / 1卷 / 02期
基金：
澳大利亚研究理事会; 澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词：
SARS-CoV-2; HLA; peptide presentation; structural biology; spike protein; T-CELL IMMUNITY; COVID-19; RECOGNITION;
D O I：
10.3390/biophysica1020015
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The SARS-CoV-2 virus responsible for the COVID-19 pandemic has caused significant morbidity and mortality worldwide. With the remarkable advances in medical research, vaccines were developed to prime the human immune system and decrease disease severity. Despite these achievements, the fundamental basis of immunity to the SARS-CoV-2 virus is still largely undefined. Here, we solved the crystal structure of three spike-derived peptides presented by three different HLA molecules, and determined the stability of the overall peptide-HLA complexes formed. The peptide presentation of spike-derived peptides can influence the way in which CD8+ T cells can recognise infected cells, clear infection, and therefore, control the outcome of the disease.
引用
收藏
页码：194 / 203
页数：10
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