Hostile bile limits anti-cancer immunity

被引：1
|
作者：
Parathan, Pavitha [1 ,2 ,3 ]
Mielke, Lisa A. [1 ,2 ,3 ]
机构：
[1] Olivia Newton John Canc Res Inst, Heidelberg, Vic, Australia
[2] La Trobe Univ, Sch Canc Med, Heidelberg, Vic, Australia
[3] La Trobe Univ, La Trobe Inst Mol Sci, Bundoora, Vic, Australia
来源：
IMMUNITY | 2024年 / 57卷 / 04期
关键词：
D O I：
10.1016/j.immuni.2024.03.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Various microbial metabolites promote cell transformation. In this issue of Immunity , Cong et al. show that deoxycholic acid (DCA), a microbial metabolite of bile, promotes tumor growth by suppressing antitumor CD8 + T cell responses via dysregulation of calcium efflux.
引用
收藏
页码：834 / 836
页数：3
相关论文
共 50 条
  • [31] Laminarin promotes anti-cancer immunity by the maturation of dendritic cells
    Song, Kyeongeun
    Xu, Li
    Zhang, Wei
    Cai, Yun
    Jang, Bian
    Oh, Junghwan
    Jin, Jun-O
    ONCOTARGET, 2017, 8 (24) : 38554 - 38567
  • [32] Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer Therapy
    Li, Ying-Ying
    Feun, Lynn G.
    Thongkum, Angkana
    Tu, Chiao-Hui
    Chen, Shu-Mei
    Wangpaichitr, Medhi
    Wu, Chunjing
    Kuo, Macus T.
    Savaraj, Niramol
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (06)
  • [33] Manipulating RHO-DIAPH Signaling to Activate Anti-Cancer Immunity
    Howard, A. M.
    Alberts, A. S.
    MOLECULAR BIOLOGY OF THE CELL, 2015, 26
  • [34] Suppression of anti-cancer immunity by regulatory T cells: Back to the future
    Orentas, RJ
    Kohler, ME
    Johnson, BD
    SEMINARS IN CANCER BIOLOGY, 2006, 16 (02) : 137 - 149
  • [35] Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity
    Papadas, Athanasios
    Huang, Yun
    Cicala, Alexander
    Dou, Yaling
    Fields, Matteo
    Gibbons, Alicia
    Hong, Duncan
    Lagal, Daniel J.
    Quintana, Victoria
    Rizo, Alejandro
    Zomalan, Brolyn
    Asimakopoulos, Fotis
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2023, 51 (06) : 2017 - 2028
  • [36] Cancer Associated Fibroblasts-An Impediment to Effective Anti-Cancer T Cell Immunity
    Koppensteiner, Lilian
    Mathieson, Layla
    O'Connor, Richard A.
    Akram, Ahsan R.
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [37] Adjuvant cationic nanoliposomes induce anti-cancer immunity in a murine model of breast cancer
    Meraz, Ismail M.
    Savage, David J.
    Gu, Jianhua
    Rhudy, Jessica
    Serda, Rita E.
    CANCER RESEARCH, 2014, 74 (19)
  • [38] Modified peptides in anti-cancer vaccines: are we eventually improving anti-tumour immunity?
    Iero, Manuela
    Filipazzi, Paola
    Castelli, Chiara
    Belli, Filiberto
    Valdagni, Riccardo
    Parmiani, Giorgio
    Patuzzo, Roberto
    Santinami, Mario
    Rivoltini, Licia
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2009, 58 (07) : 1159 - 1167
  • [39] Modified peptides in anti-cancer vaccines: are we eventually improving anti-tumour immunity?
    Manuela Iero
    Paola Filipazzi
    Chiara Castelli
    Filiberto Belli
    Riccardo Valdagni
    Giorgio Parmiani
    Roberto Patuzzo
    Mario Santinami
    Licia Rivoltini
    Cancer Immunology, Immunotherapy, 2009, 58 : 1159 - 1167
  • [40] Mesoporous Silicon Particles for the Presentation of Tumor Antigens and Adjuvant for Anti-Cancer Immunity
    Meraz, I. M.
    Melendez, B.
    Gu, J.
    Serda, R. E.
    CANCER RESEARCH, 2011, 71
12345