Role of Mesenchymal Stem/Stromal Cells (MSCs) and MSC-Derived Extracellular Vesicles (EVs) in Prevention of Telomere Length Shortening, Cellular Senescence, and Accelerated Biological Aging

被引：6

作者：

Arellano, Myrna Y. Gonzalez ^{[1
,2
,3
]}

Vanheest, Matthew ^{[2
]}

Emmadi, Sravya ^{[2
]}

Abdul-Hafez, Amal ^{[1
,2
]}

Ibrahim, Sherif Abdelfattah ^{[1
,2
,4
]}

Thiruvenkataramani, Ranga P. ^{[1
,2
,3
]}

Teleb, Rasha S. ^{[1
,2
,5
]}

Omar, Hady ^{[1
]}

Kesaraju, Tulasi ^{[1
]}

Mohamed, Tarek ^{[1
,2
,3
]}

Madhukar, Burra V. ^{[1
,2
]}

Omar, Said A. ^{[1
,2
,3
]}

机构：

[1] Michigan State Univ, Coll Human Med, Dept Pediat & Human Dev, Div Neonatol, E Lansing, MI 48824 USA

[2] Michigan State Univ, Coll Human Med, Dept Epidemiol & Biostat, E Lansing, MI 48824 USA

[3] Sparrow Hosp, Reg Neonatal Intens Care Unit, Lansing, MI 48912 USA

[4] Mansoura Univ, Fac Med, Histol & Cell Biol Dept, Mansoura 35516, Egypt

[5] South Valley Univ, Qena Fac Med, Dept Pediat & Neonatol, Qena 83523, Egypt

来源：

BIOENGINEERING-BASEL | 2024年 / 11卷 / 06期

关键词：

telomere length; biological age; mesenchymal stem cells; extracellular vesicles; exosomes;

D O I：

10.3390/bioengineering11060524

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Biological aging is defined as a progressive decline in tissue function that eventually results in cell death. Accelerated biologic aging results when the telomere length is shortened prematurely secondary to damage from biological or environmental stressors, leading to a defective reparative mechanism. Stem cells therapy may have a potential role in influencing (counteract/ameliorate) biological aging and maintaining the function of the organism. Mesenchymal stem cells, also called mesenchymal stromal cells (MSCs) are multipotent stem cells of mesodermal origin that can differentiate into other types of cells, such as adipocytes, chondrocytes, and osteocytes. MSCs influence resident cells through the secretion of paracrine bioactive components such as cytokines and extracellular vesicles (EVs). This review examines the changes in telomere length, cellular senescence, and normal biological age, as well as the factors contributing to telomere shortening and accelerated biological aging. The role of MSCs-especially those derived from gestational tissues-in prevention of telomere shortening (TS) and accelerated biological aging is explored. In addition, the strategies to prevent MSC senescence and improve the antiaging therapeutic application of MSCs and MSC-derived EVs in influencing telomere length and cellular senescence are reviewed.

引用

页数：18

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