Neurological Complications of Cannabinoids

被引:0
|
作者
Humayun, Mariyam [1 ]
Suarez, Jose I. [2 ,3 ,4 ]
Shah, Vishank A. [2 ,3 ,4 ]
机构
[1] Univ Illinois, Dept Neurol, Chicago, IL USA
[2] Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD USA
[3] Johns Hopkins Univ, Sch Med, Dept Anesthesiol, Baltimore, MD USA
[4] Johns Hopkins Univ, Sch Med, Dept Crit Care Med, Baltimore, MD USA
关键词
cannabis; THC; cannabinoids; neurological complications; substance abuse; RECREATIONAL MARIJUANA USE; ENDOCANNABINOID SYSTEM; ISCHEMIC-STROKE; TOBACCO; SMOKING; DELTA-9-TETRAHYDROCANNABINOL; VASOCONSTRICTION; PSYCHOSIS; ABUSE; USERS;
D O I
10.1055/s-0044-1787570
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Cannabinoid use, particularly for recreational purposes, is increasing exponentially across all age groups, especially in younger populations, due to its perceived low risk and legalization. While cannabinoids may be largely considered as safe, there is mounting evidence of increased risk of systemic and neurological complications through their interaction with the poorly understood endocannabinoid receptor network within the central nervous system and other organ systems. Acute cannabinoid exposure can cause neuropsychiatric symptoms in addition to altering cerebral blood flow, leading to cerebrovascular complications such as ischemic stroke, subarachnoid hemorrhage, and reversible cerebral vasoconstriction syndrome (RCVS). Chronic use, particularly among adolescents, may be associated with increased risk of long-term cognitive deficits, schizophrenia, and other neuropsychiatric effects. Synthetic cannabinoids have increased potency, with reports of causing profound neurological complications including coma, seizures, posterior reversible encephalopathy syndrome, and RCVS. Despite increasing evidence, the quality of literature describing neurologic complications with cannabinoids remains limited to case series and retrospective cohort studies, with significant confounding factors such as concomitant use of other illicit drugs, limiting interpretation. In this review, we summarize the effect of cannabinoids on the neurologic system and associated neurological complications.
引用
收藏
页码:430 / 440
页数:11
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