Subxiphoid versus lateral intercostal thoracoscopic thymectomy for suspected thymoma: Results of a randomized controlled trial

Objective: This trial was to evaluate the ef fi cacy of subxiphoid approach thoracoscopic thymectomy for postoperative pain control and length of hospital stay compared with a lateral intercostal approach thoracoscopic thymectomy. Methods: This multicenter, open-label, randomized clinical superiority trial enrolled 101 eligible participants clinically diagnosed with Masaoka-Koga I-II thymoma between August 15, 2021, and February 15, 2022. Each enrolled participant was randomized and underwent subxiphoid approach thoracoscopic thymectomy or lateral intercostal approach thoracoscopic thymectomy. A per-protocol analysis for each coprimary outcome was performed in addition to the main intentionto-treat analysis. Results: In the analysis for the coprimary outcomes, the pain Visual Analog Scale score area under the curve at 0 to 7 days was lower in the subxiphoid approach thoracoscopic thymectomy group than in the lateral intercostal approach thoracoscopic thymectomy group (difference, - 4.82; 98.3 % CI, - 8.84 to - 0.80). However, there was no signi fi cant difference between the 2 groups in the length of hospital stay (difference, 0.318; 98.3 % CI, - 0.190 to 0.825) or cumulative opioid consumption after surgery (difference, - 4.630; 98.3 % CI, - 9.530 to 0.272). All patients underwent complete resection, and there was no signi fi cant difference (7.84 % vs 8.00 % , P = 1.000) in the rate of complications between the 2 groups. No recurrence or death occurred in the postoperative 6 months. Conclusions: This study found improved pain and similar length of hospital stay associated with the subxiphoid approach compared with the lateral intercostal approach in patients with suspected Masaoka-Koga I-II thymoma. (J Thorac Cardiovasc Surg 2024;168:290-8)