Immune Responses in Controllers of HIV Infection

被引：11

作者：

Kwaa, Abena K. ^{[1
]}

Blankson, Joel N. ^{[1
]}

机构：

[1] Johns Hopkins Med, Dept Med, Ctr AIDS Res, Baltimore, MD 21205 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2024年 / 42卷

关键词：

HIV; elite controllers; viremic controllers; chronic progressors; IMMUNODEFICIENCY-VIRUS TYPE-1; CD8(+) T-CELLS; NATURAL-KILLER-CELLS; MEMORY B-CELL; ELITE CONTROLLERS; NEUTRALIZING ANTIBODIES; REPLICATION CAPACITY; VIRAL REPLICATION; TH17; CELLS; HLA-B;

D O I：

10.1146/annurev-immunol-083122-035233

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Elite controllers are a heterogeneous group of people living with HIV who control viral replication without antiretroviral therapy. There is substantial evidence that at least some elite controllers are infected with replication-competent virus, thus they may serve as a model of a functional cure of HIV. The mechanisms responsible for virologic control have been actively studied. The most objective data support CD8(+) T cell-based mechanisms of control, but other immune responses, mediated by antibodies and natural killer cells, may also play a role in controlling viral replication. In this article, we review the evidence for different mechanisms of immune control in these remarkable individuals.

引用

页码：21 / 33

页数：13

共 133 条

[41] A whole-genome association study of major determinants for host control of HIV-1 [J].

Fellay, Jacques ;

Shianna, Kevin V. ;

Ge, Dongliang ;

Colombo, Sara ;

Ledergerber, Bruno ;

Weale, Mike ;

Zhang, Kunlin ;

Gumbs, Curtis ;

Castagna, Antonella ;

Cossarizza, Andrea ;

Cozzi-Lepri, Alessandro ;

De Luca, Andrea ;

Easterbrook, Philippa ;

Francioli, Patrick ;

Mallal, Simon ;

Martinez-Picado, Javier ;

Miro, Jose M. ;

Obel, Niels ;

Smith, Jason P. ;

Wyniger, Josiane ;

Descombes, Patrick ;

Antonarakis, Stylianos E. ;

Letvin, Norman L. ;

McMichael, Andrew J. ;

Haynes, Barton F. ;

Telenti, Amalio ;

Goldstein, David B. .

SCIENCE, 2007, 317 (5840) :944-947

[42] HIV Controllers with HLA-DRB1*13 and HLA-DQB1*06 Alleles Have Strong, Polyfunctional Mucosal CD4+ T-Cell Responses [J].

Ferre, April L. ;

Hunt, Peter W. ;

McConnell, Delandy H. ;

Morris, Megan M. ;

Garcia, Juan C. ;

Pollard, Richard B. ;

Yee, Hal F., Jr. ;

Martin, Jeffrey N. ;

Deeks, Steven G. ;

Shacklett, Barbara L. .

JOURNAL OF VIROLOGY, 2010, 84 (21) :11020-11029

[43] Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller [J].

Freund, Natalia T. ;

Wang, Haoqing ;

Scharf, Louise ;

Nogueira, Lilian ;

Horwitz, Joshua A. ;

Bar-On, Yotam ;

Golijanin, Jovana ;

Sievers, Stuart A. ;

Sok, Devin ;

Cai, Hui ;

Lorenzi, Julio C. Cesar ;

Halper-Stromberg, Ariel ;

Toth, Ildiko ;

Piechocka-Trocha, Alicja ;

Gristick, Harry B. ;

van Gils, Marit J. ;

Sanders, Rogier W. ;

Wang, Lai-Xi ;

Seaman, Michael S. ;

Burton, Dennis R. ;

Gazumyan, Anna ;

Walker, Bruce D. ;

West, Anthony P., Jr. ;

Bjorkman, Pamela J. ;

Nussenzweig, Michel C. .

SCIENCE TRANSLATIONAL MEDICINE, 2017, 9 (373)

[44] Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication [J].

Friedrich, Thomas C. ;

Valentine, Laura E. ;

Yant, Levi J. ;

Rakasz, Eva G. ;

Piaskowski, Shari M. ;

Furlott, Jessica R. ;

Weisgrau, Kimberly L. ;

Burwitz, Benjamin ;

May, Gemma E. ;

Leon, Enrique J. ;

Soma, Taeko ;

Napoe, Gnankang ;

Capuano, Saverio V., III ;

Wilson, Nancy A. ;

Watkins, David I. .

JOURNAL OF VIROLOGY, 2007, 81 (07) :3465-3476

[45] Immunoregulatory T Cells May Be Involved in Preserving CD4 T Cell Counts in HIV-Infected Long-Term Nonprogressors and Controllers [J].

Gaardbo, Julie C. ;

Ronit, Andreas ;

Hartling, Hans J. ;

Gjerdrum, Lise M. R. ;

Springborg, Karoline ;

Ralfkiaer, Elisabeth ;

Thorsteinsson, Kristina ;

Ullum, Henrik ;

Andersen, Ase B. ;

Nielsen, Susanne D. .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2014, 65 (01) :10-18

[46] Deep Phenotypic Analysis of Blood and Lymphoid T and NK Cells From HIV plus Controllers and ART-Suppressed Individuals [J].

George, Ashley F. ;

Luo, Xiaoyu ;

Neidleman, Jason ;

Hoh, Rebecca ;

Vohra, Poonam ;

Thomas, Reuben ;

Shin, Min-Gyoung ;

Lee, Madeline J. ;

Blish, Catherine A. ;

Deeks, Steven G. ;

Greene, Warner C. ;

Lee, Sulggi A. ;

Roan, Nadia R. .

FRONTIERS IN IMMUNOLOGY, 2022, 13

[47] Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors [J].

Gonzalez, Nuria ;

McKee, Krisha ;

Lynch, Rebecca M. ;

Georgiev, Ivelin S. ;

Jimenez, Laura ;

Grau, Eulalia ;

Yuste, Eloisa ;

Kwong, Peter D. ;

Mascola, John R. ;

Alcami, Jose .

PLOS ONE, 2018, 13 (03)

[48] The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection [J].

Goonetilleke, Nilu ;

Liu, Michael K. P. ;

Salazar-Gonzalez, Jesus F. ;

Ferrari, Guido ;

Giorgi, Elena ;

Ganusov, Vitaly V. ;

Keele, Brandon F. ;

Learn, Gerald H. ;

Turnbull, Emma L. ;

Salazar, Maria G. ;

Weinhold, Kent J. ;

Moore, Stephen ;

Letvin, Norman ;

Haynes, Barton F. ;

Cohen, Myron S. ;

Hraber, Peter ;

Bhattacharya, Tanmoy ;

Borrow, Persephone ;

Perelson, Alan S. ;

Hahn, Beatrice H. ;

Shaw, George M. ;

Korber, Bette T. ;

McMichael, Andrew J. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (06) :1253-1272

[49] HIV control: Is getting there the same as staying there? [J].

Goulder, Philip ;

Deeks, Steven G. .

PLOS PATHOGENS, 2018, 14 (11)

[50] Gag-Positive Reservoir Cells Are Susceptible to HIV-Specific Cytotoxic T Lymphocyte Mediated Clearance [J].

Graf, Erin H. ;

Pace, Matthew J. ;

Peterson, Bennett A. ;

Lynch, Lindsay J. ;

Chukwulebe, Steve B. ;

Mexas, Angela M. ;

Shaheen, Farida ;

Martin, Jeffrey N. ;

Deeks, Steven G. ;

Connors, Mark ;

Migueles, Stephen A. ;

O'Doherty, Una .

PLOS ONE, 2013, 8 (08)

← 1 2 3 4 5 6 7 8 9 10 →