Immune Responses in Controllers of HIV Infection

被引：11

作者：

Kwaa, Abena K. ^{[1
]}

Blankson, Joel N. ^{[1
]}

机构：

[1] Johns Hopkins Med, Dept Med, Ctr AIDS Res, Baltimore, MD 21205 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2024年 / 42卷

关键词：

HIV; elite controllers; viremic controllers; chronic progressors; IMMUNODEFICIENCY-VIRUS TYPE-1; CD8(+) T-CELLS; NATURAL-KILLER-CELLS; MEMORY B-CELL; ELITE CONTROLLERS; NEUTRALIZING ANTIBODIES; REPLICATION CAPACITY; VIRAL REPLICATION; TH17; CELLS; HLA-B;

D O I：

10.1146/annurev-immunol-083122-035233

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Elite controllers are a heterogeneous group of people living with HIV who control viral replication without antiretroviral therapy. There is substantial evidence that at least some elite controllers are infected with replication-competent virus, thus they may serve as a model of a functional cure of HIV. The mechanisms responsible for virologic control have been actively studied. The most objective data support CD8(+) T cell-based mechanisms of control, but other immune responses, mediated by antibodies and natural killer cells, may also play a role in controlling viral replication. In this article, we review the evidence for different mechanisms of immune control in these remarkable individuals.

引用

页码：21 / 33

页数：13

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