Ameliorating microalgal OMEGA production using omics platforms

被引：8

作者：

Mariam, Iqra ^{[1
]}

Bettiga, Maurizio ^{[2
,3
]}

Rova, Ulrika ^{[1
]}

Christakopoulos, Paul ^{[1
]}

Matsakas, Leonidas ^{[1
]}

Patel, Alok ^{[1
]}

机构：

[1] Lulea Univ Technol, Dept Civil Environm & Nat Resources Engn, Div Chem Engn, Biochem Proc Engn, SE-97187 Lulea, Sweden

[2] Chalmers Univ Technol, Dept Life Sci LIFE, Div Ind Biotechnol, SE-41296 Gothenburg, Sweden

[3] Italbiotec Srl Soc Benefit, Innovat Unit, Milan, Italy

来源：

TRENDS IN PLANT SCIENCE | 2024年 / 29卷 / 07期

基金：

瑞典研究理事会;

关键词：

NANNOCHLOROPSIS-OCEANICA CCMP1779; DIATOM PHAEODACTYLUM-TRICORNUTUM; POLYUNSATURATED FATTY-ACIDS; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; LIPID-ACCUMULATION; FUNCTIONAL-CHARACTERIZATION; CRYPTHECODINIUM-COHNII; BIOSYNTHESIS; TRANSCRIPTOME;

D O I：

10.1016/j.tplants.2024.01.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Over the past decade, the focus on omega (w)-3 fatty acids from microalgae has intensified due to their diverse health benefits. Bioprocess optimization has notably increased w-3 fatty acid yields, yet understanding of the genetic architecture and metabolic pathways of high-yielding strains remains limited. Leveraging genomics, transcriptomics, proteomics, and metabolomics tools can provide vital system-level insights into native w-3 fatty acid-producing microalgae, further boosting production. In this review, we explore 'omics' studies uncovering alternative pathways for w-3 fatty acid synthesis and genome-wide regulation in response to cultivation parameters. We also emphasize potential targets to fine-tune in order to enhance yield. Despite progress, an integrated omics platform is essential to overcome current bottlenecks in optimizing the process for w-3 fatty acid production from microalgae, advancing this crucial field.

引用

收藏

页码：799 / 813

页数：15

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