Ameliorating microalgal OMEGA production using omics platforms

被引：8
作者：
Mariam, Iqra [1 ]
Bettiga, Maurizio [2 ,3 ]
Rova, Ulrika [1 ]
Christakopoulos, Paul [1 ]
Matsakas, Leonidas [1 ]
Patel, Alok [1 ]
机构：
[1] Lulea Univ Technol, Dept Civil Environm & Nat Resources Engn, Div Chem Engn, Biochem Proc Engn, SE-97187 Lulea, Sweden
[2] Chalmers Univ Technol, Dept Life Sci LIFE, Div Ind Biotechnol, SE-41296 Gothenburg, Sweden
[3] Italbiotec Srl Soc Benefit, Innovat Unit, Milan, Italy
来源：
TRENDS IN PLANT SCIENCE | 2024年 / 29卷 / 07期
基金：
瑞典研究理事会;
关键词：
NANNOCHLOROPSIS-OCEANICA CCMP1779; DIATOM PHAEODACTYLUM-TRICORNUTUM; POLYUNSATURATED FATTY-ACIDS; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; LIPID-ACCUMULATION; FUNCTIONAL-CHARACTERIZATION; CRYPTHECODINIUM-COHNII; BIOSYNTHESIS; TRANSCRIPTOME;
D O I：
10.1016/j.tplants.2024.01.002
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Over the past decade, the focus on omega (w)-3 fatty acids from microalgae has intensified due to their diverse health benefits. Bioprocess optimization has notably increased w-3 fatty acid yields, yet understanding of the genetic architecture and metabolic pathways of high-yielding strains remains limited. Leveraging genomics, transcriptomics, proteomics, and metabolomics tools can provide vital system-level insights into native w-3 fatty acid-producing microalgae, further boosting production. In this review, we explore 'omics' studies uncovering alternative pathways for w-3 fatty acid synthesis and genome-wide regulation in response to cultivation parameters. We also emphasize potential targets to fine-tune in order to enhance yield. Despite progress, an integrated omics platform is essential to overcome current bottlenecks in optimizing the process for w-3 fatty acid production from microalgae, advancing this crucial field.
引用
收藏
页码：799 / 813
页数：15
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