The liver as a cytokine factory working on mRNA blueprints for cancer immunotherapy

被引：6

作者：

Berraondo, Pedro ^{[1
,2
,3
,4
]}

Gomis, Gabriel ^{[1
,2
,3
]}

Melero, Ignacio ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Cima Univ Navarra, Program Immunol & Immunotherapy, Pamplona, Spain

[2] Navarra Inst Hlth Res IDISNA, Pamplona, Spain

[3] Canc Ctr Clin Univ Navarra CCUN, Pamplona, Spain

[4] Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain

[5] Clin Univ Navarra, Dept Immunol & Oncol, Pamplona, Spain

[6] Univ Oxford, Nuffield Dept Med, Oxford, England

来源：

CANCER CELL | 2024年 / 42卷 / 04期

关键词：

D O I：

10.1016/j.ccell.2024.02.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

mRNA has the potential to encode both vaccines and immunomodulatory proteins for cancer immunotherapy. In this issue, Beck et al. report on lipopolyplexed mRNAs encoding albumin-stabilized interleukin2 to transduce liver cells. These mRNAs attain antitumor efficacy on subcutaneous mouse tumors even if malignant cells lack major histocompatibility complex class I (MHC class I) expression.

引用

页码：502 / 504

页数：3

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