Alcohol-alcohol cross-coupling enabled by SH2 radical sorting

被引：58

作者：

Chen, Ruizhe ^{[1
]}

Intermaggio, Nicholas E. ^{[1
]}

Xie, Jiaxin ^{[1
]}

Rossi-Ashton, James A. ^{[1
]}

Gould, Colin A. ^{[1
]}

Martin, Robert T. ^{[1
]}

Alcazar, Jesus ^{[2
]}

MacMillan, David W. C. ^{[1
]}

机构：

[1] Princeton Univ, Merck Ctr Catalysis, Princeton, NJ 08544 USA

[2] Janssen Cilag SA, Discovery Chem, Janssen Res & Dev, C Jarama 75A, Toledo 45007, Spain

来源：

SCIENCE | 2024年 / 383卷 / 6689期

基金：

美国国家科学基金会;

关键词：

BOND-DISSOCIATION; MECHANISM;

D O I：

10.1126/science.adl5890

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alcohols represent a functional group class with unparalleled abundance and structural diversity. In an era of chemical synthesis that prioritizes reducing time to target and maximizing exploration of chemical space, harnessing these building blocks for carbon-carbon bond-forming reactions is a key goal in organic chemistry. In particular, leveraging a single activation mode to form a new C(sp(3))-C(sp(3)) bond from two alcohol subunits would enable access to an extraordinary level of structural diversity. In this work, we report a nickel radical sorting-mediated cross-alcohol coupling wherein two alcohol fragments are deoxygenated and coupled in one reaction vessel, open to air.

引用

页码：1350 / 1357

页数：8

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