Changes in Anticholinergic Burden in Parkinson's Disease After Deep Brain Stimulation

被引：0

作者：

Jiao, Jocelyn ^{[1
,2
]}

Brumbach, Barbara H. ^{[4
]}

Hantke, Nathan ^{[2
,5
]}

Wilhelmi, Morgan ^{[2
]}

Bonilla, Christian ^{[3
]}

Safarpour, Delaram ^{[2
]}

机构：

[1] Stanford Neurosci Hlth Ctr, 213 Quarry Rd, MC 9575, Palo Alto, CA 94303 USA

[2] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR USA

[3] Oregon Hlth & Sci Univ, Sch Med, Portland, OR USA

[4] Oregon Hlth & Sci Univ, Oregon Hlth & Sci Univ Portland State Univ, Sch Publ Hlth, Biostat & Design Program, Portland, OR USA

[5] Vet Affairs Portland Hlth Care Syst, Mental Hlth & Clin Neurosci Div, Portland, OR USA

来源：

NEUROMODULATION | 2024年 / 27卷 / 03期

关键词：

Anticholinergic medication burden; anticholinergic side effects; cognitive decline; deep brain stimulation; Parkinson ' s disease; SUBTHALAMIC NUCLEUS; GLOBUS-PALLIDUS; CHOLINESTERASE-INHIBITORS; RISK SCALES; COGNITION; DRUGS;

D O I：

10.1016/j.neurom.2023.11.001

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: This study aimed to evaluate the effect of deep brain stimulation (DBS) on anticholinergic burden in Parkinson ' s disease (PD) and the association of anticholinergic burden with cognition. Materials and Methods: A retrospective chart review in patients with PD who underwent bilateral subthalamic nucleus (STN) or globus pallidus internus (GPi) DBS from 2010 to 2020 reviewed medications with anticholinergic burden at baseline, six months, and one year ( N = 216) after surgery. The cumulative anticholinergic burden at each visit was calculated using the Anticholinergic Risk Scale (ARS). Results: ARS scores were significantly lower for patients six months and one year after surgery than at baseline ( z = 6.58, p < 0.0001; z = 6.99, p < 0.0001). Change in ARS scores at both six months and one year were driven by down-titration of PD medications ( z = 9.35, p < 0.0001; z = 8.61, p < 0.0001), rather than changes in pain, psychiatric, or urinary medications with anticholinergic effects. There was no signi fi cant difference in change in ARS scores at one year between targets ( t = 0.41, p = 0.68). In addition, there was no signi fi cant association between anticholinergic burden and cognitive performance. Conclusion: GPi and STN DBS are associated with decreased anticholinergic burden due to PD medications in the first year after surgery.

引用

页码：538 / 543

页数：6

共 37 条

[1] Adverse Effects of Anticholinergic Drugs on Cognition and Mobility: Cutoff for Impairment in a Cross-Sectional Study in Young-Old and Old-Old Adults [J].