Vaginal microbiomes show ethnic evolutionary dynamics and positive selection of Lactobacillus adhesins driven by a long-term niche-specific process

被引：10

作者：

Wei, Xin ^{[1
,2
,3
]}

Tsai, Ming-Shian ^{[4
]}

Liang, Liang ^{[4
]}

Jiang, Liuyiqi ^{[1
,2
]}

Hung, Chia-Jui ^{[4
,5
]}

Jelliffe-Pawlowski, Laura ^{[6
]}

Rand, Larry ^{[7
]}

Snyder, Michael ^{[4
]}

Jiang, Chao ^{[1
,2
,3
]}

机构：

[1] Zhejiang Univ, Life Sci Inst, MOE Key Lab Biosyst Homeostasis & Protect, Hangzhou 310030, Zhejiang, Peoples R China

[2] Zhejiang Univ, Life Sci Inst, Zhejiang Prov Key Lab Canc Mol Cell Biol, Hangzhou 310030, Zhejiang, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China

[4] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA

[5] Stanford Univ, Dept Biomed Informat, Sch Med, Stanford, CA 94305 USA

[6] Univ Calif San Francisco, Sch Med, Dept Epidemiol & Biostat, San Francisco, CA 94158 USA

[7] Univ Calif San Francisco, Sch Med, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94158 USA

来源：

CELL REPORTS | 2024年 / 43卷 / 04期

关键词：

GARDNERELLA-VAGINALIS; ATOPOBIUM-VAGINAE; BACTERIAL VAGINOSIS; ALIGNMENT; HEALTH; DIVERSITY; WOMEN; TOOL; IDENTIFICATION; VISUALIZATION;

D O I：

10.1016/j.celrep.2024.114078

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The vaginal microbiome's composition varies among ethnicities. However, the evolutionary landscape of the vaginal microbiome in the multi -ethnic context remains understudied. We perform a systematic evolutionary analysis of 351 vaginal microbiome samples from 35 multi -ethnic pregnant women, in addition to two validation cohorts, totaling 462 samples from 90 women. Microbiome alpha diversity and community state dynamics show strong ethnic signatures. Lactobacillaceae have a higher ratio of non -synonymous to synonymous polymorphism and lower nucleotide diversity than non-Lactobacillaceae in all ethnicities, with a large repertoire of positively selected genes, including the mucin-binding and cell wall anchor genes. These evolutionary dynamics are driven by the long-term evolutionary process unique to the human vaginal niche. Finally, we propose an evolutionary model reflecting the environmental niches of microbes. Our study reveals the extensive ethnic signatures in vaginal microbial ecology and evolution, highlighting the importance of studying the host-microbiome ecosystem from an evolutionary perspective.

引用

页数：30