Human cardiac metabolism

被引：17

作者：

Bornstein, Marc R. ^{[1
]}

Tian, Rong ^{[2
]}

Arany, Zoltan ^{[1
]}

机构：

[1] Univ Penn, Cardiovasc Inst, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Univ Washington, Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA

来源：

CELL METABOLISM | 2024年 / 36卷 / 07期

关键词：

FREE FATTY-ACID; HIGH-ENERGY PHOSPHATE; CORONARY-ARTERY-DISEASE; MYOCARDIAL GLUCOSE-UPTAKE; LEFT-VENTRICULAR FUNCTION; MAGNETIC-RESONANCE-SPECTROSCOPY; POSITRON-EMISSION-TOMOGRAPHY; REDUCED EJECTION FRACTION; IDIOPATHIC DILATED CARDIOMYOPATHY; DEPENDENT DIABETES-MELLITUS;

D O I：

10.1016/j.cmet.2024.06.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The heart is the most metabolically active organ in the human body, and cardiac metabolism has been studied for decades. However, the bulk of studies have focused on animal models. The objective of this review is to summarize specifically what is known about cardiac metabolism in humans. Techniques available to study human cardiac metabolism are first discussed, followed by a review of human cardiac metabolism in health and in heart failure. Mechanistic insights, where available, are reviewed, and the evidence for the contribution of metabolic insufficiency to heart failure, as well as past and current attempts at metabolism -based therapies, is also discussed.

引用

页码：1456 / 1481

页数：26

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