Ten cyclopentanoid monoterpenes from the whole plant of Rehmannia piasezkii maxim

被引：0
作者：
Zhou, Jie [1 ]
Shi, Guoru [1 ]
Zhang, Wanqi [1 ]
Chen, Ruoyun [1 ]
Yu, Shishan [1 ]
Yu, Dequan [1 ]
Liu, Yanfei [1 ,2 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, 1 Xiannongtan St, Beijing 100050, Peoples R China
来源：
FITOTERAPIA | 2024年 / 175卷
关键词：
Rehmannia piasezkii maxim; Scrophulariaceae; Cyclopentanoid monoterpenes; Hepatoprotective activity; IRIDOID GLYCOSIDES; RADIX; ROOTS;
D O I：
10.1016/j.fitote.2024.105968
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ten new cyclopentanoid monoterpenes ( 1 <inverted exclamation> 10 ) were isolated from the whole plant of Rehmannia piasezkii . The structures of these compounds were elucidated based on spectroscopic data analysis. In in -vitro assays, compounds 3 , 7 , and 9 exhibited weak hepatoprotective activities against APAP-induced HepG2 cell damage. Compound 9 exhibited protective effect on hapassocin carbon tetrachloride model.
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