Synthesis and biological evaluation of tetrazole fused imidazopyridine derivatives as anticancer agents

被引：5

作者：

Vanam, Narendhar Reddy ^{[1
]}

Anireddy, Jaya Shree ^{[1
]}

机构：

[1] Jawaharlal Nehru Technol Univ, Inst Sci & Technol, Ctr Chem Sci & Technol, Hyderabad, India

来源：

CHEMICAL DATA COLLECTIONS | 2023年 / 48卷

关键词：

Zolpidem; Alpidem; Cephalosporin and anticancer activity; DESIGN; INHIBITORS; OPTIMIZATION; SERIES;

D O I：

10.1016/j.cdc.2023.101092

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of tetrazole fused imidazopyridine derivatives (12a-j) were synthesized and evaluated for their cytotoxic activity against three human cancer cell lines (MCF7, A549, MDA MB-231). All these synthesized compounds were confirmed by H-1 NMR, (CNMR)-C-13 and mass spectral analysis. Among them, compounds 12b, 12c, 12d, 12h, 12i and 12j showed more potent activity than the positive control doxorubicin.

引用

页数：7

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