Mycobacterium tuberculosis infection induces a novel type of cell death: Ferroptosis

被引：4

作者：

Wang, Jianjun ^{[1
]}

Cao, Hui ^{[2
]}

Xie, Yiping ^{[1
]}

Xu, Zi ^{[1
]}

Li, Yujie ^{[1
]}

Luo, Hao ^{[3
]}

机构：

[1] Jiangsu Univ, Kunshan Hosp, Dept Clin Lab, Suzhou 215300, Peoples R China

[2] Jiangsu Prov Ctr Dis Control & Prevent, Dept Food & Nutr Safety, Nanjing 210009, Jiangsu, Peoples R China

[3] Second Peoples Hosp Kunshan, Dept Clin Lab, Suzhou, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2024年 / 177卷

基金：

中国国家自然科学基金;

关键词：

Ferroptosis; Biomarkers; Lipid peroxides; M; tuberculosis; LIPID-PEROXIDATION; INNATE IMMUNITY; NECROPTOSIS; MACROPHAGES; APOPTOSIS; DEFENSE;

D O I：

10.1016/j.biopha.2024.117030

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Ferroptosis is a lipid peroxidation-driven and iron-dependent form of programmed cell death, which is involved in a variety of physical processes and multiple diseases. Numerous reports have demonstrated that ferroptosis is closely related to the pathophysiological processes of Mycobacterium tuberculosis (M. tuberculosis) infection and is characterized by the accumulation of excess lipid peroxides on the cell membrane. In this study, the various functions of ferroptosis, and the therapeutic strategies and diagnostic biomarkers of tuberculosis, were summarized. Notably, this review provides insights into the molecular mechanisms and functions of M. tuberculosisinduced ferroptosis, suggesting potential future therapeutic and diagnostic markers for tuberculosis.

引用

页数：8

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