Radical Oxygen Species, Oxidized Low-Density Lipoproteins, and Lectin-like Oxidized Low-Density Lipoprotein Receptor 1: A Vicious Circle in Atherosclerotic Process

被引:8
作者
Munno, Marco [1 ]
Mallia, Alice [1 ,2 ]
Greco, Arianna [1 ]
Modafferi, Gloria [1 ]
Banfi, Cristina [1 ]
Eligini, Sonia [1 ]
机构
[1] Ctr Cardiol Monzino, Unit Funct Prote Metabol & Network Anal, I-20138 Milan, Italy
[2] Univ Pavia, Dipartimento Biol & Biotecnol Lazzaro Spallanzani, I-27100 Pavia, Italy
关键词
radical oxygen species; ox-LDL; LOX-1; atherosclerosis; FOAM CELL-FORMATION; ARTERY ENDOTHELIAL-CELLS; SMOOTH-MUSCLE-CELLS; OX-LDL RECEPTOR-1; NF-KAPPA-B; ADHESION MOLECULE EXPRESSION; NEGATIVE FEEDBACK-REGULATION; ISCHEMIA-REPERFUSION INJURY; ACUTE MYOCARDIAL-INFARCTION; INDUCED LOX-1 EXPRESSION;
D O I
10.3390/antiox13050583
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Atherosclerosis is a complex condition that involves the accumulation of lipids and subsequent plaque formation in the arterial intima. There are various stimuli, cellular receptors, and pathways involved in this process, but oxidative modifications of low-density lipoprotein (ox-LDL) are particularly important in the onset and progression of atherosclerosis. Ox-LDLs promote foam-cell formation, activate proinflammatory pathways, and induce smooth-muscle-cell migration, apoptosis, and cell death. One of the major receptors for ox-LDL is LOX-1, which is upregulated in several cardiovascular diseases, including atherosclerosis. LOX-1 activation in endothelial cells promotes endothelial dysfunction and induces pro-atherogenic signaling, leading to plaque formation. The binding of ox-LDLs to LOX-1 increases the generation of reactive oxygen species (ROS), which can induce LOX-1 expression and oxidize LDLs, contributing to ox-LDL generation and further upregulating LOX-1 expression. This creates a vicious circle that is amplified in pathological conditions characterized by high plasma levels of LDLs. Although LOX-1 has harmful effects, the clinical significance of inhibiting this protein remains unclear. Further studies both in vitro and in vivo are needed to determine whether LOX-1 inhibition could be a potential therapeutic target to counteract the atherosclerotic process.
引用
收藏
页数:30
相关论文
共 50 条
  • [31] Deleterious role of endothelial lectin-like oxidized low-density lipoprotein receptor-1 in ischaemia/reperfusion cerebral injury
    Akhmedov, Alexander
    Bonetti, Nicole R.
    Reiner, Martin F.
    Spescha, Remo D.
    Amstalden, Heidi
    Merlini, Mario
    Gaul, Daniel S.
    Diaz-Canestro, Candela
    Briand-Schumacher, Sylvie
    Spescha, Rebecca S.
    Semerano, Aurora
    Giacalone, Giacomo
    Savarese, Gianluigi
    Montecucco, Fabrizio
    Kulic, Luka
    Nitsch, Roger M.
    Matter, Christian M.
    Kullak-Ublick, Gerd A.
    Sessa, Maria
    Luescher, Thomas F.
    Beer, Juerg H.
    Liberale, Luca
    Camici, Giovanni G.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2019, 39 (11) : 2233 - 2245
  • [32] Lectin-Like Oxidized Low-Density Lipoprotein 1 Receptor in a Reduced Uteroplacental Perfusion Pressure Rat Model of Preeclampsia
    Morton, Jude S.
    Abdalvand, Ali
    Jiang, Yanyan
    Sawamura, Tatsuya
    Uwiera, Richard R. E.
    Davidge, Sandra T.
    HYPERTENSION, 2012, 59 (05) : 1014 - 1020
  • [33] Rice bran peptides target lectin-like oxidized low-density lipoprotein receptor-1 to ameliorate atherosclerosis
    Mu, Jianfei
    Li, Jiajia
    Chen, Zhongxu
    Chen, Yajuan
    Lin, Qinlu
    Zhang, Lingyu
    Fang, Yong
    Liang, Ying
    FOOD & FUNCTION, 2025, 16 (03) : 867 - 884
  • [34] Biosensors to detect low-density lipoprotein and oxidized low-density lipoprotein in cardiovascular disease
    Ranjbari, Sara
    Ritchie, Leona A.
    Arefinia, Reza
    Kesharwani, Prashant
    Sahebkar, Amirhossein
    SENSORS AND ACTUATORS A-PHYSICAL, 2024, 365
  • [35] Increased Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Expression in the Maternal Vasculature of Women With Preeclampsia Role for Peroxynitrite
    Sankaralingam, Sowndramalingam
    Xu, Yi
    Sawamura, Tatsuya
    Davidge, Sandra T.
    HYPERTENSION, 2009, 53 (02) : 270 - U310
  • [36] Relationship between lectin-like oxidized low-density lipoprotein receptor 1 expression and preoperative echogenic findings of vulnerable carotid plaque
    Saito, Atsushi
    Fujimura, Miki
    Inoue, Takashi
    Shimizu, Hiroaki
    Tominaga, Teiji
    ACTA NEUROCHIRURGICA, 2010, 152 (04) : 589 - 595
  • [37] Endothelial damage in white coat hypertension: role of lectin-like oxidized low-density lipoprotein-1
    Yavuzer, S.
    Yavuzer, H.
    Cengiz, M.
    Erman, H.
    Altiparmak, M. R.
    Korkmazer, B.
    Balci, H.
    Simsek, G.
    Yaldiran, A. L.
    Karter, Y.
    Uzun, H.
    JOURNAL OF HUMAN HYPERTENSION, 2015, 29 (02) : 92 - 98
  • [38] Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 concentrations and prognosis of aneurysmal subarachnoid hemorrhage
    Lin, Qun
    Ba, Hua-Jun
    Dai, Jun-Xia
    Sun, Jun
    Lu, Chuan
    Chen, Mao-Hua
    Chen, Xian-Dong
    Cai, Jian-Yong
    CLINICA CHIMICA ACTA, 2020, 500 : 54 - 58
  • [39] Lectin-like Oxidized Low-Density Lipoprotein Receptor 1 Signal Is a Potent Biomarker and Therapeutic Target for Human Rheumatoid Arthritis
    Ishikawa, Masahiro
    Ito, Hiromu
    Akiyoshi, Miki
    Kume, Noriaki
    Yoshitomi, Hiroyuki
    Mitsuoka, Hirokazu
    Tanida, Shimei
    Murata, Koichi
    Shibuya, Hideyuki
    Kasahara, Takashi
    Kakino, Akemi
    Fujita, Yoshiko
    Sawamura, Tatsuya
    Yasuda, Tadashi
    Nakamura, Takashi
    ARTHRITIS AND RHEUMATISM, 2012, 64 (04): : 1024 - 1034
  • [40] Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 Is Inversely Correlated with the Activity of ANCA-Associated Vasculitis
    Yoon, Taejun
    Ahn, Sung Soo
    Song, Jason Jungsik
    Park, Yong-Beom
    Lee, Sang-Won
    YONSEI MEDICAL JOURNAL, 2020, 61 (08) : 720 - 725