Genetic studies of type 2 diabetes, and microvascular complications of diabetes

被引：3

作者：

Imamura, Minako ^{[1
,2
]}

Maeda, Shiro ^{[1
,2
]}

机构：

[1] Univ Ryukyus, Grad Sch Med, Dept Adv Genom & Lab Med, Nishihara, Okinawa 9030215, Japan

[2] Univ Ryukyus Hosp, Div Clin Lab & Blood Transfus, Nishihara, Okinawa 9300215, Japan

来源：

DIABETOLOGY INTERNATIONAL | 2024年 / 15卷 / 04期

关键词：

Type; 2; diabetes; Microvascular complications of diabetes; Genome-wide association study; Polygenic risk score; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; RISK-FACTORS; JAPANESE PATIENTS; KIDNEY-DISEASE; RETINOPATHY; HERITABILITY; METAANALYSIS; VARIANTS; POLYMORPHISMS;

D O I：

10.1007/s13340-024-00727-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genome-wide association studies (GWAS) have significantly advanced the identification of genetic susceptibility variants associated with complex diseases. As of 2023, approximately 800 variants predisposing individuals to the risk of type 2 diabetes (T2D) were identified through GWAS, and the majority of studies were predominantly conducted in European populations. Despite the shared nature of the majority of genetic susceptibility loci across diverse ethnic populations, GWAS in non-European populations, including Japanese and East Asian populations, have revealed population-specific T2D loci. Currently, polygenic risk scores (PRSs), encompassing millions of associated variants, can identify individuals with a higher T2D risk than the general population. However, GWAS focusing on microvascular complications of diabetes have identified a limited number of disease-susceptibility loci. Ongoing efforts are crucial to enhance the applicability of PRS for all ethnic groups and unravel the genetic architecture of microvascular complications of diabetes.

引用

页码：699 / 706

页数：8

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