Deleterious Anti-In fl ammatory Macrophage Recruitment in Early Post-Infarction Phase Unraveling the IL-6/MCP-1/STAT3 Axis

被引：6

作者：

Paccalet, Alexandre ^{[1
]}

Badawi, Sally ^{[1
]}

Pillot, Bruno ^{[1
]}

Augeul, Lionel ^{[1
]}

Mechtouff, Laura ^{[1
]}

Harhous, Zeina ^{[1
]}

Gouriou, Yves ^{[1
]}

Paillard, Melanie ^{[1
]}

Breuilly, Marine ^{[2
]}

Amaz, Camille ^{[3
]}

Varillon, Yvonne ^{[3
]}

Leboube, Simon ^{[1
]}

Brun, Camille

Prieur, Cyril ^{[3
]}

Rioufol, Gilles ^{[3
]}

Mewton, Nathan ^{[1
,3
,4
]}

Ovize, Michel ^{[1
]}

Bidaux, Gabriel ^{[1
]}

Bochaton, Thomas ^{[1
,3
,5
]}

Da Silva, Claire Crola

机构：

[1] Univ Lyon, Univ Claude Bernard Lyon 1, Lab CarMeN, INSERM,INRA,INSA Lyon,IRIS Team, Bron, France

[2] Univ Claude Bernard Lyon 1, CNRS, CIQLE,LyMIC,LABEX CORTEX,Inserm,US7, Struct Federat Rech Sante Lyon Est,UAR3453, Lyon, France

[3] Hosp Civils Lyon, Ctr Invest Clin Lyon CIC 1407, Inserm, Lyon, France

[4] Hosp Civils Lyon, Louis Pradel Hosp, Intens Cardiol Care Div, Bron, France

[5] Univ Claude Bernard Lyon 1, Lyon, France

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2024年 / 9卷 / 05期

关键词：

IL-6; in flammation; macrophages; MCP-1; myocardial infarction; STAT3; CLINICAL-OUTCOMES; PROGNOSTIC VALUE; INTERLEUKIN-6; ACCUMULATION; INHIBITION; MYOCARDIUM; INJURY; TRIAL; IL-6;

D O I：

10.1016/j.jacbts.2024.01.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Using a translational approach with an ST -segment myocardial infarction (STEMI) cohort and mouse model of myocardial infarction, we highlighted the role of the secreted IL -6 and MCP -1 cytokines and the STAT3 pathway in heart macrophage recruitment and activation. Cardiac myocytes secrete IL -6 and MCP -1 in response to hypoxic stress, leading to a recruitment and/or polarization of anti-in flammatory macrophages via the STAT3 pathway. In our preclinical model of myocardial infarction, neutralization of IL -6 and MCP -1 or STAT3 pathway reduced infarct size. Together, our data demonstrate that anti-in flammatory macrophages can be deleterious in the acute phase of STEMI. (J Am Coll Cardiol Basic Trans Science 2024;9:593 -604) (c) 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：593 / 604

页数：12

共 39 条

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