Deleterious Anti-In fl ammatory Macrophage Recruitment in Early Post-Infarction Phase Unraveling the IL-6/MCP-1/STAT3 Axis

被引：6

作者：

Paccalet, Alexandre ^{[1
]}

Badawi, Sally ^{[1
]}

Pillot, Bruno ^{[1
]}

Augeul, Lionel ^{[1
]}

Mechtouff, Laura ^{[1
]}

Harhous, Zeina ^{[1
]}

Gouriou, Yves ^{[1
]}

Paillard, Melanie ^{[1
]}

Breuilly, Marine ^{[2
]}

Amaz, Camille ^{[3
]}

Varillon, Yvonne ^{[3
]}

Leboube, Simon ^{[1
]}

Brun, Camille

Prieur, Cyril ^{[3
]}

Rioufol, Gilles ^{[3
]}

Mewton, Nathan ^{[1
,3
,4
]}

Ovize, Michel ^{[1
]}

Bidaux, Gabriel ^{[1
]}

Bochaton, Thomas ^{[1
,3
,5
]}

Da Silva, Claire Crola

机构：

[1] Univ Lyon, Univ Claude Bernard Lyon 1, Lab CarMeN, INSERM,INRA,INSA Lyon,IRIS Team, Bron, France

[2] Univ Claude Bernard Lyon 1, CNRS, CIQLE,LyMIC,LABEX CORTEX,Inserm,US7, Struct Federat Rech Sante Lyon Est,UAR3453, Lyon, France

[3] Hosp Civils Lyon, Ctr Invest Clin Lyon CIC 1407, Inserm, Lyon, France

[4] Hosp Civils Lyon, Louis Pradel Hosp, Intens Cardiol Care Div, Bron, France

[5] Univ Claude Bernard Lyon 1, Lyon, France

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2024年 / 9卷 / 05期

关键词：

IL-6; in flammation; macrophages; MCP-1; myocardial infarction; STAT3; CLINICAL-OUTCOMES; PROGNOSTIC VALUE; INTERLEUKIN-6; ACCUMULATION; INHIBITION; MYOCARDIUM; INJURY; TRIAL; IL-6;

D O I：

10.1016/j.jacbts.2024.01.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Using a translational approach with an ST -segment myocardial infarction (STEMI) cohort and mouse model of myocardial infarction, we highlighted the role of the secreted IL -6 and MCP -1 cytokines and the STAT3 pathway in heart macrophage recruitment and activation. Cardiac myocytes secrete IL -6 and MCP -1 in response to hypoxic stress, leading to a recruitment and/or polarization of anti-in flammatory macrophages via the STAT3 pathway. In our preclinical model of myocardial infarction, neutralization of IL -6 and MCP -1 or STAT3 pathway reduced infarct size. Together, our data demonstrate that anti-in flammatory macrophages can be deleterious in the acute phase of STEMI. (J Am Coll Cardiol Basic Trans Science 2024;9:593 -604) (c) 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：593 / 604

页数：12

共 39 条

[1] Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture [J].

Ancey, C ;

Corbi, P ;

Froger, J ;

Delwail, A ;

Wijdenes, J ;

Gascan, H ;

Potreau, D ;

Lecron, JC .

CYTOKINE, 2002, 18 (04) :199-205

[2] Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D [J].

Bochaton, T. ;

Crola-Da-Silva, C. ;

Pillot, B. ;

Villedieu, C. ;

Ferreras, L. ;

Alam, M. R. ;

Thibault, H. ;

Strina, M. ;

Gharib, A. ;

Ovize, M. ;

Baetz, D. .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2015, 84 :61-69

[3] Heat Shock Protein 70 as a Biomarker of Clinical Outcomes After STEMI [J].

Bochaton, Thomas ;

Paccalet, Alexandre ;

Jeantet, Pierre ;

Da Silva, Claire Crola ;

Cartier, Regine ;

Prieur, Cyril ;

Jossan, Claire ;

Bonnefoy-Cudraz, Eric ;

Mewton, Nathan ;

Ovize, Michel .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 75 (01) :122-124

[4]

Borrayo-Sánchez G, 2010, CIR CIR, V78, P25

[5] Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man [J].

Boyle, Andrew J. ;

Yeghiazarians, Yerem ;

Shih, Henry ;

Hwang, Joy ;

Ye, Jianqin ;

Sievers, Rich ;

Zheng, Daiwei ;

Palasubramaniam, Jath ;

Palasubramaniam, Dharshan ;

Karschimkus, Connie ;

Whitbourn, Robert ;

Jenkins, Alicia ;

Wilson, Andrew M. .

JOURNAL OF TRANSLATIONAL MEDICINE, 2011, 9

[6] Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction [J].

Broch, Kaspar ;

Anstensrud, Anne Kristine ;

Woxholt, Sindre ;

Sharma, Kapil ;

Tollefsen, Ingvild Maria ;

Bendz, Bjorn ;

Aakhus, Svend ;

Ueland, Thor ;

Amundsen, Brage Hoyem ;

Damas, Jan Kristian ;

Berg, Erlend Sturle ;

Bjorkelund, Elisabeth ;

Bendz, Christina ;

Hopp, Einar ;

Kleveland, Ola ;

Stensaeth, Knut Haakon ;

Opdahl, Anders ;

Klow, Nils-Einar ;

Seljeflot, Ingebjorg ;

Andersen, Geir Oystein ;

Wiseth, Rune ;

Aukrust, Pal ;

Gullestad, Lars .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 77 (15) :1845-1855

[7] Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes [J].

de Lemos, JA ;

Morrow, DA ;

Sabatine, MS ;

Murphy, SA ;

Gibson, CM ;

Antman, EM ;

McCabe, CH ;

Cannon, CP ;

Braunwald, E .

CIRCULATION, 2003, 107 (05) :690-695

[8] Interleukin-6 correlates with hemodynamic impairment during dobutamine administration in chronic heart failure [J].

Deng, MC ;

Erren, M ;

Lutgen, A ;

Zimmermann, P ;

Brisse, B ;

Schmitz, W ;

Assmann, G ;

Breithardt, G ;

Scheld, HH .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 1996, 57 (02) :129-134

[9] Interleukin-6 and the Risk of Adverse Outcomes in Patients After an Acute Coronary Syndrome: Observations From the SOLID-TIMI 52 (Stabilization of Plaque Using Darapladib-Thrombolysis in Myocardial Infarction 52) Trial [J].

Fanola, Christina L. ;

Morrow, David A. ;

Cannon, Christopher P. ;

Jarolim, Petr ;

Lukas, Mary Ann ;

Bode, Christoph ;

Hochman, Judith S. ;

Goodrich, Erica L. ;

Braunwald, Eugene ;

O'Donoghue, Michelle L. .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2017, 6 (10)

[10] Coronary Atherosclerosis, Cardiac Troponin, and Interleukin-6 in Patients With Chest Pain The PROMISE Trial Results [J].

Ferencik, Maros ;

Mayrhofer, Thomas ;

Lu, Michael T. ;

Bittner, Daniel O. ;

Emami, Hamed ;

Puchner, Stefan B. ;

Meyersohn, Nandini M. ;

Ivanov, Alexander V. ;

Adami, Elizabeth C. ;

Voora, Deepak ;

Ginsburg, Geoffrey S. ;

Januzzi, James L. ;

Douglas, Pamela S. ;

Hoffmann, Udo .

JACC-CARDIOVASCULAR IMAGING, 2022, 15 (08) :1427-1438

← 1 2 3 4 →