Outcome of patients with peritoneal metastasis from ovarian cancer treated with Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)

被引:0
作者
Foslund, Ingrid Terese [1 ,2 ]
von Magius, Sahra Aisha Vinholt [1 ,2 ]
Ainsworth, Alan Patrick [1 ,3 ,4 ]
Detlefsen, Sonke [1 ,4 ,5 ]
Fristrup, Claus Wilki [1 ,3 ]
Knudsen, Anja Oer [1 ,6 ]
Mortensen, Michael Bau [1 ,3 ,4 ]
Tarpgaard, Line Schmidt [1 ,4 ,6 ]
Jochumsen, Kirsten Marie [2 ,4 ]
Graversen, Martin [1 ,3 ,4 ,7 ]
机构
[1] Odense Univ Hosp, Odense PIPAC Ctr, Odense, Denmark
[2] Odense Univ Hosp, Dept Obstet & Gynaecol, Odense, Denmark
[3] Odense Univ Hosp, Dept Surg, Svendborg, Denmark
[4] Univ Southern Denmark, Fac Hlth Sci, Dept Clin Res, Odense, Denmark
[5] Odense Univ Hosp, Dept Pathol, Odense, Denmark
[6] Odense Univ Hosp, Dept Oncol, Odense, Denmark
[7] Odense Univ Hosp, OPEN Open Patient Data Explorat Network, Odense, Denmark
关键词
Ovarian Cancer; Peritoneal Metastasis; Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC); Peritoneal Regression Grading Score (PRGS); Quality of Life (QoL); REGRESSION GRADING SCORE; PLUS PLATINUM; SURVIVAL; PROPOSAL; WOMEN;
D O I
10.1515/pp-2023-0049
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives There are few data on Pressurized IntraPeritoneal Aerosol Chemotherapy with cisplatin and doxorubicin (PIPAC C/D) in women with primary unresectable or recurrent platinum-resistant peritoneal metastasis (PM) from ovarian cancer (OC). We evaluated survival, histological and cytological response, Quality of Life (QoL) and toxicity after PIPAC C/D in these patients.Methods Retrospective analysis of patients from the prospective PIPAC-OPC1 and -OPC2 studies. The histological response was evaluated by the Peritoneal Regression Grading Score (PRGS). QoL questionnaires were collected at baseline and after third PIPAC or 60 days. Adverse events were collected until 30 days after the last PIPAC. Demographic and survival data were analysed based on intention to treat. Response, QoL and toxicity were analysed per protocol (>= 1 PIPAC).Results Twenty-nine patients were included. Five patients (17 %) were non-accessible at PIPAC 1. One patient was excluded due to liver metastases at PIPAC 1. Thus, 23 patients had 76 PIPACs (median 2, range 1-12). Median overall survival was 8.2 months (95 % CI 4.4-10.3) from PIPAC 1. Biopsy data were available for 22 patients, and seven (32 %) patients had a major/complete histological response (PRGS <= 2) at PIPAC 3. No cytological conversions were registered. Symptoms and function scores worsened, while emotional scores improved. Three patients had severe adverse reactions (two ileus, one pulmonary embolism); no life-threatening reactions or treatment-related mortality was observed.Conclusions PIPAC C/D was feasible and induced histological regression in a substantial proportion of patients with platinum-resistant PM from OC. Larger studies are needed to evaluate impact on survival.
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页码:69 / 77
页数:9
相关论文
共 41 条
[1]   THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER QLQ-C30 - A QUALITY-OF-LIFE INSTRUMENT FOR USE IN INTERNATIONAL CLINICAL-TRIALS IN ONCOLOGY [J].
AARONSON, NK ;
AHMEDZAI, S ;
BERGMAN, B ;
BULLINGER, M ;
CULL, A ;
DUEZ, NJ ;
FILIBERTI, A ;
FLECHTNER, H ;
FLEISHMAN, SB ;
DEHAES, JCJM ;
KAASA, S ;
KLEE, M ;
OSOBA, D ;
RAZAVI, D ;
ROFE, PB ;
SCHRAUB, S ;
SNEEUW, K ;
SULLIVAN, M ;
TAKEDA, F .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (05) :365-376
[2]   Pressurised intraperitoneal aerosol chemotherapy: rationale, evidence, and potential indications [J].
Alyami, Mohammad ;
Hubner, Martin ;
Grass, Fabian ;
Bakrin, Naoual ;
Villeneuve, Laurent ;
Laplace, Nathalie ;
Passot, Guillaume ;
Glehen, Olivier ;
Kepenekian, Vahan .
LANCET ONCOLOGY, 2019, 20 (07) :E368-E377
[3]   Ovarian Cancer, Version 2.2020 [J].
Armstrong, Deborah K. ;
Alvarez, Ronald D. ;
Bakkum-Gamez, Jamie N. ;
Barroilhet, Lisa ;
Behbakht, Kian ;
Berchuck, Andrew ;
Chen, Lee-may ;
Cristea, Mihaela ;
DeRosa, Maria ;
Eisenhauer, Eric L. ;
Gershenson, David M. ;
Gray, Heidi J. ;
Grisham, Rachel ;
Hakam, Ardeshir ;
Jain, Angela ;
Karam, Amer ;
Konecny, Gottfried E. ;
Leath, Charles A., III ;
Liu, Joyce ;
Mahdi, Haider ;
Martin, Lainie ;
Matei, Daniela ;
McHale, Michael ;
McLean, Karen ;
Miller, David S. ;
O'Malley, David M. ;
Percac-Lima, Sanja ;
Ratner, Elena ;
Remmenga, Steven W. ;
Vargas, Roberto ;
Werner, Theresa L. ;
Zsiros, Emese ;
Burns, Jennifer L. ;
Engh, Anita M. .
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2021, 19 (02) :191-+
[4]   Peritoneal regression grading score (PRGS): first evidence for independent predictive and prognostic significance [J].
Baake, Janina ;
Nadiradze, Giorgi ;
Archid, Rami ;
Koenigsrainer, Alfred ;
Boesmueller, Hans ;
Reymond, Marc ;
Solass, Wiebke .
PLEURA AND PERITONEUM, 2023, 8 (02) :55-63
[5]   Prognostic impact of combined progression index based on peritoneal grading regression score and peritoneal cytology in peritoneal metastasis [J].
Benzerdjeb, Nazim ;
Durieux, Emeline ;
Tantot, Juliet ;
Isaac, Sylvie ;
Fontaine, Juliette ;
Harou, Olivier ;
Glehen, Olivier ;
Kepenekian, Vahan ;
Alyami, Mohammad ;
Villeneuve, Laurent ;
Laplace, Nathalie ;
Traverse-Glehen, Alexandra ;
Shisheboran-Devouassoux, Mojgan ;
Bakrin, Naoual .
HISTOPATHOLOGY, 2020, 77 (04) :548-559
[6]   "Platinum resistant" ovarian cancer: What is it, who to treat and how to measure benefit? [J].
Davis, Alison ;
Tinker, Anna V. ;
Friedlander, Michael .
GYNECOLOGIC ONCOLOGY, 2014, 133 (03) :624-631
[7]   Role of immunohistochemistry for interobserver agreement of Peritoneal Regression Grading Score in peritoneal metastasis [J].
Detlefsen, Sonke ;
Windedal, Tobias ;
Bibeau, Frederic ;
Bruhn, Lorke Valsoe ;
Carr, Norman ;
Graversen, Martin ;
Markowski, Katharina ;
Mortensen, Michael Bau ;
Neureiter, Daniel ;
Sempoux, Christine ;
Solass, Wiebke ;
Thinesen, Malene Theilmann ;
Fristrup, Claus .
HUMAN PATHOLOGY, 2022, 120 :77-87
[8]   Classification of surgical complications - A new proposal with evaluation in a cohort of 6336 patients and results of a survey [J].
Dindo, D ;
Demartines, N ;
Clavien, PA .
ANNALS OF SURGERY, 2004, 240 (02) :205-213
[9]   Importance of biopsy site selection for peritoneal regression grading score (PRGS) in peritoneal metastasis treated with repeated pressurized intraperitoneal aerosol chemotherapy (PIPAC) [J].
Fallah, Mojib ;
Detlefsen, Sonke ;
Ainsworth, Alan P. ;
Fristrup, Claus W. ;
Mortensen, Michael B. ;
Pfeiffer, Per ;
Tarpgaard, Line S. ;
Graversen, Martin .
PLEURA AND PERITONEUM, 2022, 7 (03) :143-148
[10]   Systematic review of pressurized intraperitoneal aerosol chemotherapy for the treatment of advanced peritoneal carcinomatosis [J].
Grass, F. ;
Vuagniaux, A. ;
Teixeira-Farinha, H. ;
Lehmann, K. ;
Demartines, N. ;
Hubner, M. .
BRITISH JOURNAL OF SURGERY, 2017, 104 (06) :669-678