I- catalyzed cascade annulation of 2-(pyridin-2-yl)acetate derivatives with N , N- dimethylenamine 2 ketones: Site-selective synthesis of functionalized indolizines

被引：0
|
作者：
Li, Yuan -Da [1 ]
Zhang, Wei-Min [1 ]
Zhao, Ke-Hua [1 ]
Zhang, Cong-Hai [1 ]
Yan, Sheng-Jiao [1 ]
机构：
[1] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resources, Minist Educ, Kunming 650091, Peoples R China
来源：
TETRAHEDRON | 2024年 / 159卷
关键词：
I2-Catalysis; Cascade annulation; Indolizines; NN-Dimethyl-enamine ketones; ONE-POT SYNTHESIS; METAL-FREE SYNTHESIS; BIOLOGICAL EVALUATION; FLUORESCENT-PROBES; CYCLIZATION; ALKYNES; DESIGN; ENAMINONES; IMIDAZOLE; HYBRIDS;
D O I：
10.1016/j.tet.2024.134015
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel synthesis method was developed for developing functionalized indolizines. In this reaction, 2-(pyridin-2yl)acetate derivatives and N , N -dimethylenamine ketones were used as substrates. All these processes were enabled by heating a mixture of starting materials in toluene and in the presence of I 2 under air. Cascade reaction resulted in the formation of two bonds and cleavage of one bond in one pot. Consequently, a number of functionalized indolizines were produced via a cascade reaction. This protocol can be used to synthesize functionalized unsymmetrical 2,4-diarylpyridines. Moreover, it is suitable for combinatorial and parallel syntheses of indolizines derivatives in a one -pot reaction and it is not a tedious multi -step reaction.
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页数：9
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