I- catalyzed cascade annulation of 2-(pyridin-2-yl)acetate derivatives with N , N- dimethylenamine 2 ketones: Site-selective synthesis of functionalized indolizines

被引：0

作者：

Li, Yuan -Da ^{[1
]}

Zhang, Wei-Min ^{[1
]}

Zhao, Ke-Hua ^{[1
]}

Zhang, Cong-Hai ^{[1
]}

Yan, Sheng-Jiao ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resources, Minist Educ, Kunming 650091, Peoples R China

来源：

TETRAHEDRON | 2024年 / 159卷

关键词：

I2-Catalysis; Cascade annulation; Indolizines; NN-Dimethyl-enamine ketones; ONE-POT SYNTHESIS; METAL-FREE SYNTHESIS; BIOLOGICAL EVALUATION; FLUORESCENT-PROBES; CYCLIZATION; ALKYNES; DESIGN; ENAMINONES; IMIDAZOLE; HYBRIDS;

D O I：

10.1016/j.tet.2024.134015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel synthesis method was developed for developing functionalized indolizines. In this reaction, 2-(pyridin-2yl)acetate derivatives and N , N -dimethylenamine ketones were used as substrates. All these processes were enabled by heating a mixture of starting materials in toluene and in the presence of I 2 under air. Cascade reaction resulted in the formation of two bonds and cleavage of one bond in one pot. Consequently, a number of functionalized indolizines were produced via a cascade reaction. This protocol can be used to synthesize functionalized unsymmetrical 2,4-diarylpyridines. Moreover, it is suitable for combinatorial and parallel syntheses of indolizines derivatives in a one -pot reaction and it is not a tedious multi -step reaction.

引用

页数：9

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