The Role of Resveratrol in Aging and Senescence: A Focus on Molecular Mechanisms

被引：7
作者：
Kohandel, Zeynab [1 ]
Darrudi, Majid [2 ]
Naseri, Kobra [3 ]
Samini, Fariborz [4 ]
Aschner, Michael [5 ]
Pourbagher-Shahri, Ali Mohammad [3 ]
Samarghandian, Saeed [6 ]
机构：
[1] Univ Tehran, Fac Sci, Dept Biol, Tehran, Iran
[2] Neyshabur Univ Med Sci, Dept Basic Sci, Neyshabur 9318614139, Iran
[3] Birjand Univ Med Sci, Sch Pharm, Dept Toxicol & Pharmacol, Birjand, Iran
[4] Mashhad Univ Med Sci, Sch Med, Dept Neurosurg, Mashhad, Iran
[5] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY USA
[6] Neyshabur Univ Med Sci, Hlth Ageing Res Ctr, Neyshabur, Iran
来源：
CURRENT MOLECULAR MEDICINE | 2024年 / 24卷 / 07期
关键词：
Resveratrol; aging; senescence; molecular mechanisms; oxidative stress; inflammation; CELLULAR SENESCENCE; CANCER; ACTIVATORS; EXPRESSION; CELLS;
D O I：
10.2174/1566524023666230602162949
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Resveratrol (Res), a polyphenol found in red wine, has been shown to decelerate aging, the progressive loss of physiological integrity and cellular senescence, characterized by the inability to progress through the cell cycle. No successful clinical trials have yet to be completed in humans on dose limitations. Yet, the potent anti-aging and anti-senescence efficacy of Res has been documented in several in vivo animal models. In this review, we highlight the molecular mechanisms of Res efficacy in anti-aging disorders, such as diabetes, neurodegenerative disorders, eye diseases, and cardiovascular diseases.
引用
收藏
页码：867 / 875
页数：9
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