Targeted discovery of unusual diterpenoids with anti-fungal activity from the root of Euphorbia lathyris

被引：3

作者：

Wang, Yiwei ^{[1
]}

Xu, Shu ^{[1
]}

Zhang, Guodong ^{[1
]}

Li, Pirui ^{[1
]}

Liu, Chenyang ^{[1
]}

Zhou, Jiarui ^{[2
]}

Feng, Xu ^{[1
]}

Li, Linwei ^{[1
]}

Chen, Yu ^{[1
]}

机构：

[1] Jiangsu Prov & Chinese Acad Sci, Nanjing Bot Garden Mem Sun Yat Sen, Jiangsu Prov Engn Res Ctr Ecocultivat & High Value, Jiangsu Key Lab Res & Utilizat Plant Resources,Ins, Nanjing 210014, Peoples R China

[2] Soochow Univ, Suzhou 215006, Peoples R China

来源：

PHYTOCHEMISTRY | 2024年 / 225卷

基金：

中国国家自然科学基金;

关键词：

Euphorbia lathyris; Euphorbiaceae; Diterpenes; Anti-fungal activity; SEEDS;

D O I：

10.1016/j.phytochem.2024.114193

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lathyrisone A (1), a diterpene with an undescribed tricyclic 6/6/6 fused carbon skeleton, along with spirolathyrisins B-D (3-5), three diterpenes with a rare [4.5.0] spirocyclic carbon skeleton, and one known compound (2) were isolated from the roots of Euphorbia lathyris. Their chemical structures were characterized by extensive spectroscopic analysis, X-ray crystallography, ECD and quantum chemistry calculation. A plausible biosynthetic pathway for compounds 1-5 was proposed, which suggested it is a competitive pathway for ingenol biosynthesis in the plant. The anti-fungal activities of these compounds were tested, especially, compound 2 showed stronger anti-fungal activities against Fusarium oxysporum and Alternaria alternata than the positive control fungicide thiophanate-methyl. The preliminary structure-activity relationship of compounds 1-5 was also discussed. These results not only expanded the chemical diversities of E. lathyris, but also provided a lead compound for the control of plant pathogens.

引用

页数：8

共 21 条

[1]

Abramovits William, 2013, Skinmed, V11, P111

[2] An expeditious procedure for the isolation of ingenol from the seeds of Euphorbia lathyris [J].