A systematic review of allometric scaling exponents for IgG mAbs

被引：0
|
作者：
Rowland, Simon Peter [1 ]
Nixon, Emma [2 ]
Mohan, Krithika [3 ]
Wang, Qianwen [4 ]
Yates, James W. T. [2 ]
机构：
[1] Haleon, Bldg 5,First Floor, Weybridge KT13 0NY, Surrey, England
[2] GSK, DMPK Modelling, Stevenage, England
[3] DMPK Modelling, 1000 Winter St, Waltham, MA USA
[4] GSK, CPMS Infect Dis & Vaccine, London, England
来源：
XENOBIOTICA | 2024年 / 54卷 / 09期
关键词：
pharmacokinetics; allometric scaling; modelling mAb PK; cynomolgus monkey; mAb global scaling exponents; THERAPEUTIC MONOCLONAL-ANTIBODIES; HUMAN PHARMACOKINETICS; PREDICTION;
D O I：
10.1080/00498254.2024.2383925
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Increasing complexity of mAbs in development creates challenges in predicting human pharmacokinetic (PK) parameters from preclinical data. The aim of this analysis was to identify optimal allometric scaling exponents.Data were extracted from literature to create a central database (currently the largest available published database) of two-compartment model parameters for mAbs (n = 59) in cynomolgus monkey (CM) and human.Global allometric exponents were calculated and drug-dependent factors were investigated as potential variables in determining the optimal scaling factor.The global exponents for scaling CM mAb PK data were 0.74 (CL), 0.80 (CL with Fc-modified mAbs excluded), 0.44 (CL with Fc-modified mAbs only), 0.71 (Q), 1.12 (V1), and 0.99 (V2). These values are in line with previously published literature values.
引用
收藏
页码：609 / 614
页数：6
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