Immunotherapeutic Strategies Targeting Breast Cancer Stem Cells

被引:1
|
作者
Vasileiou, Maria [1 ]
Diamantoudis, Sotirios Charalampos [2 ]
Tsianava, Christina [3 ]
Nguyen, Nam P. [4 ]
机构
[1] Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Athens 15771, Greece
[2] Aristotle Univ Thessaloniki, Sch Hlth Sci, Dept Pharm, Thessaloniki 54124, Greece
[3] Univ Patras, Sch Hlth Sci, Dept Pharm, Patras 26504, Greece
[4] Howard Univ, Dept Radiat Oncol, Washington, DC 20060 USA
关键词
immunotherapy; breast cancer; cancer stem cells; immunological profile; CSC-targeted therapies; vaccines; CAR T cells; CAR-T-CELLS; DENDRITIC CELLS; PROGENITOR CELLS; INITIATING CELLS; DOWN-REGULATION; EMERGING ROLE; TUMOR-CELLS; IN-VITRO; RESISTANCE; EXPRESSION;
D O I
10.3390/curroncol31060232
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Breast cancer is the most commonly diagnosed cancer in women and is a leading cause of cancer death in women worldwide. Despite the implementation of multiple treatment options, including immunotherapy, breast cancer treatment remains a challenge. In this review, we aim to summarize present challenges in breast cancer immunotherapy and recent advancements in overcoming treatment resistance. We elaborate on the inhibition of signaling cascades, such as the Notch, Hedgehog, Hippo, and WNT signaling pathways, which regulate the self-renewal and differentiation of breast cancer stem cells and, consequently, disease progression and survival. Cancer stem cells represent a rare population of cancer cells, likely originating from non-malignant stem or progenitor cells, with the ability to evade immune surveillance and develop resistance to immunotherapeutic treatments. We also discuss the interactions between breast cancer stem cells and the immune system, including potential agents targeting breast cancer stem cell-associated signaling pathways, and provide an overview of the emerging approaches to breast cancer stem cell-targeted immunotherapy. Finally, we consider the development of breast cancer vaccines and adoptive cellular therapies, which train the immune system to recognize tumor-associated antigens, for eliciting T cell-mediated responses to target breast cancer stem cells.
引用
收藏
页码:3040 / 3063
页数:24
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