Unveiling altered connectivity between cognitive networks and cerebellum in schizophrenia

被引:2
|
作者
Biondi, Margherita [1 ]
Marino, Marco [2 ,3 ]
Mantini, Dante [3 ]
Spironelli, Chiara [1 ,2 ]
机构
[1] Univ Padua, Padova Neurosci Ctr, Padua, Italy
[2] Univ Padua, Dept Gen Psychol, Padua, Italy
[3] Katholieke Univ Leuven, Movement Control & Neuroplast Res Grp, Tervuursevest 101, B-3001 Leuven, Belgium
关键词
Resting state networks; Brain connectivity; Cerebellum; Schizophrenia; Seed-based analysis; Cognitive deficits; STATE FUNCTIONAL CONNECTIVITY; RESTING-STATE; DEFAULT MODE; HUMAN BRAIN; NEGATIVE SYMPTOMS; VERBAL FLUENCY; AUTOBIOGRAPHICAL MEMORY; ATTENTION NETWORK; CORTICAL NETWORKS; SPATIAL NEGLECT;
D O I
10.1016/j.schres.2024.06.044
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Cognitive functioning is a crucial aspect in schizophrenia (SZ), and when altered it has devastating effects on patients' quality of life and treatment outcomes. Several studies suggested that they could result from altered communication between the cortex and cerebellum. However, the neural correlates underlying these impairments have not been identified. In this study, we investigated resting state functional connectivity (rsFC) in SZ patients, by considering the interactions between cortical networks supporting cognition and cerebellum. In addition, we investigated the relationship between SZ patients' rsFC and their symptoms. We used fMRI data from 74 SZ patients and 74 matched healthy controls (HC) downloaded from the publicly available database SchizConnect. We implemented a seed-based connectivity approach to identify altered functional connections between specific cortical networks and cerebellum. We considered ten commonly studied resting state networks, whose functioning encompasses specific cognitive functions, and the cerebellum, whose involvement in supporting cognition has been recently identified. We then explored the relationship between altered rsFC values and Positive and Negative Syndrome Scale (PANSS) scores. The SZ group showed increased connectivity values compared with HC group for cortical networks involved in attentive processes, which were also linked to PANSS items describing attention and language-related processing. We also showed decreased connectivity between cerebellar regions, and increased connectivity between them and attentive networks, suggesting the contribution of cerebellum to attentive and affective deficits. In conclusion, our findings highlighted the link between negative symptoms in SZ and altered connectivity within the cerebellum and between the same and cortical networks supporting cognition.
引用
收藏
页码:47 / 58
页数:12
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