Mannan-Decorated Lipid Calcium Phosphate Nanoparticle Vaccine Increased the Antitumor Immune Response by Modulating the Tumor Microenvironment

被引:4
|
作者
Wu, Liusheng [1 ,2 ]
Yang, Lei [1 ]
Qian, Xinye [1 ]
Hu, Wang [1 ]
Wang, Shuang [1 ]
Yan, Jun [1 ]
机构
[1] Tsinghua Univ, Beijing Tsinghua Changgung Hosp, Ctr Hepatobil Pancreat Dis, Sch Med, Beijing 100084, Peoples R China
[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 19077, Singapore
关键词
nanoparticle vaccine; antitumor immune response; calcium phosphate (CaP); tumor microenvironment; review; IN-SITU VACCINATION; COVID-19; VACCINATION; CANCER; IMMUNIZATION; DELIVERY; SARS-COV-2; CHILDREN; MICROPARTICLES; DOXORUBICIN; COMPLEXES;
D O I
10.3390/jfb15080229
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
With the rapid development of tumor immunotherapy, nanoparticle vaccines have attracted much attention as potential therapeutic strategies. A systematic review and analysis must be carried out to investigate the effect of mannose modification on the immune response to nanoparticles in regulating the tumor microenvironment, as well as to explore its potential clinical application in tumor therapy. Despite the potential advantages of nanoparticle vaccines in immunotherapy, achieving an effective immune response in the tumor microenvironment remains a challenge. Tumor immune escape and the overexpression of immunosuppressive factors limit its clinical application. Therefore, our review explored how to intervene in the immunosuppressive mechanism in the tumor microenvironment through the use of mannan-decorated lipid calcium phosphate nanoparticle vaccines to improve the efficacy of immunotherapy in patients with tumors and to provide new ideas and strategies for the field of tumor therapy.
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页数:25
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