Visible-Light-Driven Synthesis of 6-Aroyl Benzimidazo[1,2-c]quinazolines from N-Cyanobenzimidazoles and α-Keto Acids by Radical Relay Cyclization

被引：3

作者：

Hu, Yang ^{[1
,2
]}

Liu, Cheng-Liang ^{[1
,2
]}

He, Wen-Tao ^{[1
,2
]}

Liu, Li-Hong ^{[1
,2
]}

Li, Jiang-Sheng ^{[1
,2
]}

Li, Zhi-Wei ^{[1
,2
]}

Liu, Han-Wen ^{[1
,2
]}

Li, Wen-Sheng ^{[3
]}

机构：

[1] Changsha Univ Sci & Technol, Sch Chem & Chem Engn, Hunan Prov Key Lab Mat Protect Elect Power & Trans, Changsha 410114, Peoples R China

[2] Changsha Univ Sci & Technol, Hunan Prov Key Lab Cytochem, Changsha 410114, Peoples R China

[3] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 27卷 / 34期

关键词：

Heteroaryl ketones; Benzimidazoquinazolines; Cyanamides; Keto acids; Radical reactions; Photocatalysis; DECARBOXYLATIVE ACYLATION; CYANAMIDE ALKENES; CHEMISTRY; OXIDATION; ACCESS; QUINAZOLINONES; DERIVATIVES;

D O I：

10.1002/ejoc.202400563

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A diverse array of 6-aroyl benzimidazo[1,2-c]quinazolines was successfully synthesized using easily obtainable N-cyanobenzimidazoles and alpha-keto acids, facilitated by photoredox catalysis. A mechanistic investigation revealed that this methodology might involve both photoredox and energy transfer catalytic cycles, generating acyl radicals that subsequently promote radical relay cyclization.

引用

页数：5

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