Evaluation of Anticancer Activity of Nucleoside-Nitric Oxide Photo-Donor Hybrids

被引：0

作者：

Marchesi, Elena ^{[1
]}

Melloni, Elisabetta ^{[2
,3
]}

Casciano, Fabio ^{[2
,3
]}

Pozza, Elena ^{[2
]}

Argazzi, Roberto ^{[1
,4
]}

De Risi, Carmela ^{[1
]}

Preti, Lorenzo ^{[5
]}

Perrone, Daniela ^{[5
]}

Navacchia, Maria Luisa ^{[4
]}

机构：

[1] Univ Ferrara, Dept Chem Pharmaceut & Agr Sci, I-44121 Ferrara, Italy

[2] Univ Ferrara, Dept Translat Med, I-44121 Ferrara, Italy

[3] Univ Ferrara, LTTA Ctr, I-44121 Ferrara, Italy

[4] Natl Res Council Italy CNR, Inst Organ Synth & Photoreact ISOF, I-40129 Bologna, Italy

[5] Univ Ferrara, Dept Environm & Prevent Sci, I-44121 Ferrara, Italy

来源：

MOLECULES | 2024年 / 29卷 / 14期

关键词：

nucleoside analogs; hybrid drugs; nitric oxide; photo-donor; anticancer activity; multitarget anticancer drugs; NO; MECHANISMS; COMPLEXES;

D O I：

10.3390/molecules29143383

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Herein, we report the synthesis of a new hybrid compound based on a 2 '-deoxyuridine nucleoside conjugated with a NO photo-donor moiety (dU-t-NO) via CuAAC click chemistry. Hybrid dU-t-NO, as well as two previously reported 2 '-deoxyadenosine based hybrids (dAdo-S-NO and dAdo-t-NO), were evaluated for their cytotoxic and cytostatic activities in selected cancer cell lines. dAdo-S-NO and dAdo-t-NO hybrids displayed higher activity with respect to dU-t-NO. All hybrids showed effective release of NO in the micromolar range. The photochemical behavior of the newly reported hybrid, dU-t-NO, was studied in the RKO colon carcinoma cell line, whereas the dAdo-t-NO hybrid was tested in both colon carcinoma RKO and hepatocarcinoma Hep 3B2.1-7 cell lines to evaluate the potential effect of NO released upon irradiation on cell viability. A customized irradiation apparatus for in vitro experiments was also designed.

引用

页数：19

共 46 条

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