Streptococcus dysgalactiae subsp. equisimilis infection and its intersection with Streptococcus pyogenes

被引:2
|
作者
Xie, Ouli [1 ,2 ]
Davies, Mark R. [3 ]
Tong, Steven Y. C. [1 ,4 ]
机构
[1] Univ Melbourne, Dept Infect Dis, Peter Doherty Inst Infect & Immun, Melbourne, Australia
[2] Monash Hlth, Monash Infect Dis, Melbourne, Australia
[3] Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, Melbourne, Australia
[4] Royal Melbourne Hosp, Victorian Infect Dis Serv, Peter Doherty Inst Infect & Immun, Melbourne, Australia
基金
英国医学研究理事会;
关键词
Streptococcus; Streptococcus pyogenes; Streptococcus dysgalactiae; group C/G Streptococcus; BETA-HEMOLYTIC STREPTOCOCCI; GROUP-A STREPTOCOCCUS; INVASIVE GROUP-A; LANCEFIELD-GROUP-C; FIBRONECTIN-BINDING PROTEIN; 2-COMPONENT REGULATORY SYSTEM; BACTERIAL PHEROMONE PEPTIDE; STREPTOLYSIN-S PRODUCTION; HORIZONTAL GENE-TRANSFER; ACUTE RHEUMATIC-FEVER;
D O I
10.1128/cmr.00175-23
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an increasingly recognized cause of disease in humans. Disease manifestations range from non-invasive superficial skin and soft tissue infections to life-threatening streptococcal toxic shock syndrome and necrotizing fasciitis. Invasive disease is usually associated with co-morbidities, immunosuppression, and advancing age. The crude incidence of invasive disease approaches that of the closely related pathogen, Streptococcus pyogenes. Genomic epidemiology using whole-genome sequencing has revealed important insights into global SDSE population dynamics including emerging lineages and spread of anti-microbial resistance. It has also complemented observations of overlapping pathobiology between SDSE and S. pyogenes, including shared virulence factors and mobile gene content, potentially underlying shared pathogen phenotypes. This review provides an overview of the clinical and genomic epidemiology, disease manifestations, treatment, and virulence determinants of human infections with SDSE with a particular focus on its overlap with S. pyogenes. In doing so, we highlight the importance of understanding the overlap of SDSE and S. pyogenes to inform surveillance and disease control strategies.
引用
收藏
页数:42
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