RETRACTED: Comprehensive review for non-coding RNAs: From mechanisms to therapeutic applications (Retracted article. See vol. 239, 2025)

被引：17
作者：
Zhang, YanJun [1 ]
Zhan, Lijuan [1 ]
Jiang, Xue [1 ]
Tang, Xiaozhu [2 ]
机构：
[1] Jiangsu Coll Nursing, Coll Pharm & Tradit Chinese Med, Huaian 223005, Jiangsu, Peoples R China
[2] Nanjing Univ Chinese Med, Sch Med & Holist Integrat Med, Nanjing 210023, Peoples R China
来源：
BIOCHEMICAL PHARMACOLOGY | 2024年 / 224卷
基金：
中国国家自然科学基金;
关键词：
Non-coding RNAs; Disease; Cancer; Biomarkers; Therapeutics; CIRCULAR RNA; EXTRACELLULAR VESICLES; CLINICAL-APPLICATION; POTENTIAL BIOMARKER; PROSTATE-CANCER; EMERGING ROLES; LUNG-CANCER; CELLS; EXOSOMES; MIR-155;
D O I：
10.1016/j.bcp.2024.116218
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Non-coding RNAs (ncRNAs) are an assorted collection of transcripts that are not translated into proteins. Since their discovery, ncRNAs have gained prominence as crucial regulators of various biological functions across diverse cell types and tissues, and their abnormal functioning has been implicated in disease. Notably, extensive research has focused on the relationship between microRNAs (miRNAs) and human cancers, although other types of ncRNAs, such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are also emerging as significant contributors to human disease. In this review, we provide a comprehensive summary of our current knowledge regarding the roles of miRNAs, lncRNAs, and circRNAs in cancer and other major human diseases, particularly cancer, cardiovascular, neurological, and infectious diseases. Moreover, we discuss the potential utilization of ncRNAs as disease biomarkers and as targets for therapeutic interventions.
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页数：20
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