Molecular Mechanisms Linking Genes and Vitamins of the Complex B Related to One-Carbon Metabolism in Breast Cancer: An In Silico Functional Database Study

被引:0
作者
Galvez-Navas, Jose Maria [1 ,2 ,3 ,4 ]
Molina-Montes, Esther [1 ,3 ,5 ]
Rodriguez-Barranco, Miguel [1 ,2 ,3 ]
Ramirez-Tortosa, Mcarmen [6 ]
Gil, Angel [3 ,6 ,7 ]
Sanchez, Maria-Jose [1 ,2 ,3 ]
机构
[1] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBER, Madrid 28029, Spain
[2] Canc Registry Granada, Andalusian Sch Publ Hlth, Campus Univ Cartuja,Cuesta Observ 4, Granada 18011, Spain
[3] Inst Invest Biosanit Ibs GRANADA, Av Madrid 15, Granada 18012, Spain
[4] Univ Granada, Int Postgrad Sch, PhD Program Nutr & Food Sci, Av Madrid 13, Granada 18012, Spain
[5] Univ Granada, Fac Pharm, Dept Nutr & Food Sci, Campus Univ Cartuja, Granada 18011, Spain
[6] Univ Granada, Fac Pharm, Dept Biochem & Mol Biol 2, Campus Univ Cartuja, Granada 18011, Spain
[7] Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr C, Madrid 28029, Spain
关键词
one-carbon metabolism; breast cancer; genes; single nucleotide polymorphisms; B-complex vitamins; computational biology; RISK; ASSOCIATION; FOLATE;
D O I
10.3390/ijms25158175
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Carcinogenesis is closely related to the expression, maintenance, and stability of DNA. These processes are regulated by one-carbon metabolism (1CM), which involves several vitamins of the complex B (folate, B2, B6, and B12), whereas alcohol disrupts the cycle due to the inhibition of folate activity. The relationship between nutrients related to 1CM (all aforementioned vitamins and alcohol) in breast cancer has been reviewed. The interplay of genes related to 1CM was also analyzed. Single nucleotide polymorphisms located in those genes were selected by considering the minor allele frequency in the Caucasian population and the linkage disequilibrium. These genes were used to perform several in silico functional analyses (considering corrected p-values < 0.05 as statistically significant) using various tools (FUMA, ShinyGO, and REVIGO) and databases such as the Kyoto Encyclopedia of Genes and Genomes (KEGG) and GeneOntology (GO). The results of this study showed that intake of 1CM-related B-complex vitamins is key to preventing breast cancer development and survival. Also, the genes involved in 1CM are overexpressed in mammary breast tissue and participate in a wide variety of biological phenomena related to cancer. Moreover, these genes are involved in alterations that give rise to several types of neoplasms, including breast cancer. Thus, this study supports the role of one-carbon metabolism B-complex vitamins and genes in breast cancer; the interaction between both should be addressed in future studies.
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