Mucosal immune tolerance at the ocular surface in health and disease

被引：67

作者：

Galletti, Jeremias G. ^{[1
]}

Guzman, Mauricio ^{[1
]}

Giordano, Mirta N. ^{[1
]}

机构：

[1] Natl Acad Med CONICET, Immunol Lab, Inst Experimental Med, Argentina Pacheco Melo 3081, RA-1425 Buenos Aires, DF, Argentina

来源：

IMMUNOLOGY | 2017年 / 150卷 / 04期

关键词：

allergic conjunctivitis; conjunctival inflammation; dry eye; mucosal tolerance; ocular mucosal immune system; ocular surface; DRY EYE DISEASE; REGULATORY T-CELLS; INFLAMMATORY-BOWEL-DISEASE; CORNEAL EPITHELIAL-CELLS; DIESEL EXHAUST PARTICLES; FACTOR-KAPPA-B; VIVO CONFOCAL MICROSCOPY; CD103(+) DENDRITIC CELLS; CIGARETTE-SMOKE EXPOSURE; ALLERGIC CONJUNCTIVITIS;

D O I：

10.1111/imm.12716

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ocular surface is constantly exposed to environmental irritants, allergens and pathogens, against which it can mount a prompt immune response to preserve its integrity. But to avoid unnecessary inflammation, the ocular surface's mucosal immune system must also discriminate between harmless and potentially dangerous antigens, a seemingly complicated task. Despite its unique features, the ocular surface is a mucosal lining, and as such, it shares some homeostatic and pathophysiological mechanisms with other mucosal surfaces. The purpose of this review is to explore the mucosal homeostatic immune function of the ocular surface in both the healthy and diseased states, with a special focus on mucosal immunology concepts. The information discussed in this review has been retrieved by PubMed searches for literature published from January 1981 to October 2016.

引用

页码：397 / 407

页数：11

共 129 条

[1] In Vivo Confocal Microscopy of Conjunctiva-Associated Lymphoid Tissue in Healthy Humans [J].

Agnifili, Luca ;

Mastropasqua, Rodolfo ;

Fasanella, Vincenzo ;

Di Staso, Silvio ;

Mastropasqua, Alessandra ;

Brescia, Lorenza ;

Mastropasqua, Leonardo .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (08) :5254-5262

[2] Factors Predicting the Ocular Surface Response to Desiccating Environmental Stress [J].

Alex, Anastasia ;

Edwards, Austin ;

Hays, J. Daniel ;

Kerkstra, Michelle ;

Shih, Amanda ;

de Paiva, Cintia S. ;

Pflugfelder, Stephen C. .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (05) :3325-3332

[3] Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells [J].

Aliberti, Julio .

MEDIATORS OF INFLAMMATION, 2016, 2016

[4] Regulatory T Cells: Molecular Actions on Effector Cells in Immune Regulation [J].

Arce-Sillas, Asiel ;

Denisse Alvarez-Luquin, Diana ;

Tamaya-Dominguez, Beatriz ;

Gomez-Fuentes, Sandra ;

Trejo-Garcia, Abel ;

Melo-Salas, Marlene ;

Cardenas, Graciela ;

Rodriguez-Ramirez, Juan ;

Adalid-Peralta, Laura .

JOURNAL OF IMMUNOLOGY RESEARCH, 2016, 2016

[5] Identification, Isolation, and Functional Assay of Regulatory T Cells [J].

Azimi, Maryam ;

Aslani, Saeed ;

Mortezagholi, Sahar ;

Salek, Amir ;

Javan, Mohammad Reza ;

Rezaiemanesh, Alireza ;

Ghaedi, Mojgan ;

Gholamzad, Mehrdad ;

Salehi, Eisa .

IMMUNOLOGICAL INVESTIGATIONS, 2016, 45 (07) :584-602

[6] Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance [J].

Baratin, Myriam ;

Foray, Chloe ;

Demaria, Olivier ;

Habbeddine, Mohamed ;

Pollet, Emeline ;

Maurizio, Julien ;

Verthuy, Christophe ;

Davanture, Suzel ;

Azukizawa, Hiroaki ;

Flores-Langarica, Adriana ;

Dalod, Marc ;

Lawrence, Toby .

IMMUNITY, 2015, 42 (04) :627-639

[7] Role of Hyperosmolarity in the Pathogenesis and Management of Dry Eye Disease: Proceedings of the OCEAN Group Meeting [J].

Baudouin, Christophe ;

Aragona, Pasquale ;

Messmer, Elisabeth M. ;

Tomlinson, Alan ;

Calonge, Margarita ;

Boboridis, Kostas G. ;

Akova, Yonca A. ;

Geerling, Gerd ;

Labetoulle, Marc ;

Rolando, Maurizio .

OCULAR SURFACE, 2013, 11 (04) :246-258

[8] Preservatives in eyedrops: The good, the bad and the ugly [J].

Baudouin, Christophe ;

Labbe, Antoine ;

Liang, Hong ;

Pauly, Aude ;

Brignole-Baudouin, Francoise .

PROGRESS IN RETINAL AND EYE RESEARCH, 2010, 29 (04) :312-334

[9] Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye [J].

Bauskar, Aditi ;

Mack, Wendy J. ;

Mauris, Jerome ;

Argueeso, Pablo ;

Heur, Martin ;

Nagel, Barbara A. ;

Kolar, Grant R. ;

Gleave, Martin E. ;

Nakamura, Takahiro ;

Kinoshita, Shigeru ;

Moradian-Oldak, Janet ;

Panjwani, Noorjahan ;

Pflugfelder, Stephen C. ;

Wilson, Mark R. ;

Fini, M. Elizabeth ;

Jeong, Shinwu .

PLOS ONE, 2015, 10 (09)

[10] Impact of wildfire smoke in Buenos Aires, Argentina, on ocular surface [J].

Berra, Martin ;

Galperin, Gustavo ;

Dawidowski, Laura ;

Tau, Julia ;

Mrquez, Isabel ;

Berra, Alejandro .

ARQUIVOS BRASILEIROS DE OFTALMOLOGIA, 2015, 78 (02) :110-114

← 1 2 3 4 5 6 7 8 9 10 →