Efficacy of Cytoreductive Surgery (CRS) plus HIPEC in Gastric Cancer with Peritoneal Metastasis: Systematic Review and Meta-Analysis

被引：6

作者：

Langellotti, Lodovica ^{[1
]}

Fiorillo, Claudio ^{[2
]}

D'Annibale, Giorgio ^{[1
]}

Panza, Edoardo ^{[1
]}

Pacelli, Fabio ^{[1
,3
]}

Alfieri, Sergio ^{[1
,2
]}

Di Giorgio, Andrea ^{[3
]}

Santullo, Francesco ^{[3
]}

机构：

[1] Catholic Univ Sacred Hearth, Gen Surg Dept, A Gemelli Med Sch, I-00168 Rome, Italy

[2] Catholic Univ Sacred Hearth, Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Digest Surg, I-00168 Rome, Italy

[3] Catholic Univ Sacred Hearth, Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Peritoneum & Retroperitoneum Surg, I-00168 Rome, Italy

来源：

CANCERS | 2024年 / 16卷 / 10期

关键词：

gastric cancer; peritoneal metastasis; cytoreductive surgery; HIPEC; HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; PHASE-III TRIAL; CARCINOMATOSIS; SURVIVAL; ADENOCARCINOMA; MORTALITY;

D O I：

10.3390/cancers16101929

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Peritoneal carcinomatosis is one of deadliest metastatic patterns of gastric cancer, being associated with a median overall survival (OS) of 4 months. Up to now, palliative systemic chemotherapy (pSC) has been the only recommended treatment. The aim of this study is to evaluate a potential survival benefit after CRS + HIPEC compared to pSC. Methods: A systematic review was conducted according to the PRISMA guidelines in March 2024. Manuscripts reporting patients with peritoneal carcinomatosis from gastric cancer treated with CRS + HIPEC were included. A meta-analysis was performed, comparing the survival results between the CRS + HIPEC and pSC groups, and the primary outcome was the comparison in terms of OS. We performed random-effects meta-analysis of odds ratios (ORs). We assessed heterogeneity using the Q2 statistic. Results: Out of the 24 papers included, 1369 patients underwent CRS + HIPEC, with a median OS range of 9.8-28.2 months; and 103 patients underwent pSC, with a median OS range of 4.9-8 months. CRS + HIPEC was associated with significantly increased survival compared to palliative systemic chemotherapy (-1.8954 (95% CI: -2.5761 to -1.2146; p < 0.001). Conclusions: CRS + HIPEC could provide survival advantages in gastric cancer peritoneal metastasis compared to pSC.

引用

页数：12

共 43 条

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