Exploring the Potential of Natural Killer Cell-Based Immunotherapy in Targeting High-Grade Serous Ovarian Carcinomas

被引：3

作者：

Kaur, Kawaljit ^{[1
]}

Sanghu, Jashan ^{[2
,3
]}

Memarzadeh, Sanaz ^{[2
,3
,4
,5
,6
]}

Jewett, Anahid ^{[1
,4
]}

机构：

[1] Univ Calif Los Angeles, Jane & Jerry Weintraub Ctr Reconstruct Biotechnol, Div Oral Biol & Med, Sch Dent, 10833 Le Conte Ave, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell R, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Mol Biol Inst, Los Angeles, CA 90095 USA

[6] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA

来源：

VACCINES | 2024年 / 12卷 / 06期

关键词：

ovarian cancer; high-grade serous ovarian cancers; immunotherapies; cytotoxicity; cytokines; IFN-gamma; natural killer cells; super-charged NK cells; TUMOR-INFILTRATING LYMPHOCYTES; REGULATORY T-CELLS; FACTOR-KAPPA-B; NK CELLS; EPITHELIAL OVARIAN; RECURRENT OVARIAN; MIRVETUXIMAB SORAVTANSINE; CANCER-PATIENTS; PHASE-II; IN-VIVO;

D O I：

10.3390/vaccines12060677

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

High-grade serous ovarian cancers (HGSOCs) likely consist of poorly differentiated stem-like cells (PDSLCs) and differentiated tumor cells. Conventional therapeutics are incapable of completely eradicating PDSLCs, contributing to disease progression and tumor relapse. Primary NK cells are known to effectively lyse PDSLCs, but they exhibit low or minimal cytotoxic potential against well-differentiated tumors. We have introduced and discussed the characteristics of super-charged NK (sNK) cells in this review. sNK cells, in comparison to primary NK cells, exhibit a significantly higher capability for the direct killing of both PDSLCs and well-differentiated tumors. In addition, sNK cells secrete significantly higher levels of cytokines, especially those known to induce the differentiation of tumors. In addition, we propose that a combination of sNK and chemotherapy could be one of the most effective strategies to eliminate the heterogeneous population of ovarian tumors; sNK cells can lyse both PDSLCs and well-differentiated tumors, induce the differentiation of PDSLCs, and could be used in combination with chemotherapy to target both well-differentiated and NK-induced differentiated tumors.

引用

页数：17

共 152 条

[1] OCEANS: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Chemotherapy With or Without Bevacizumab in Patients With Platinum-Sensitive Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer [J].

Aghajanian, Carol ;

Blank, Stephanie V. ;

Goff, Barbara A. ;

Judson, Patricia L. ;

Teneriello, Michael G. ;

Husain, Amreen ;

Sovak, Mika A. ;

Yi, Jing ;

Nycum, Lawrence R. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (17) :2039-2045

[2] Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells [J].

Alhabbab, Rowa Y. .

FRONTIERS IN GENETICS, 2020, 11

[3] Absence of PD-L1 on tumor cells is associated with reduced MHC I expression and PD-L1 expression increases in recurrent serous ovarian cancer [J].

Aust, Stefanie ;

Felix, Sophie ;

Auer, Katharina ;

Bachmayr-Heyda, Anna ;

Kenner, Lukas ;

Dekan, Sabine ;

Meier, Samuel M. ;

Gerner, Christopher ;

Grimm, Christoph ;

Pils, Dietmar .

SCIENTIFIC REPORTS, 2017, 7

[4] Epigenetic regulation of CD133 and tumorigenicity of CD133+ovarian cancer cells [J].

Baba, T. ;

Convery, P. A. ;

Matsumura, N. ;

Whitaker, R. S. ;

Kondoh, E. ;

Perry, T. ;

Huang, Z. ;

Bentley, R. C. ;

Mori, S. ;

Fujii, S. ;

Marks, J. R. ;

Berchuck, A. ;

Murphy, S. K. .

ONCOGENE, 2009, 28 (02) :209-218

[5] The systemic treatment of recurrent ovarian cancer revisited [J].

Baert, T. ;

Ferrero, A. ;

Sehouli, J. ;

O'Donnell, D. M. ;

Gonzalez-Martin, A. ;

Joly, F. ;

van der Velden, J. ;

Blecharz, P. ;

Tan, D. S. P. ;

Querleu, D. ;

Colombo, N. ;

du Bois, A. ;

Ledermann, J. A. .

ANNALS OF ONCOLOGY, 2021, 32 (06) :710-725

[6] Chimeric NKG2D Expressing T Cells Eliminate Immunosuppression and Activate Immunity within the Ovarian Tumor Microenvironment [J].

Barber, Amorette ;

Rynda, Agnieszka ;

Sentman, Charles L. .

JOURNAL OF IMMUNOLOGY, 2009, 183 (11) :6939-6947

[7] Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling [J].

Bashashati, Ali ;

Ha, Gavin ;

Tone, Alicia ;

Ding, Jiarui ;

Prentice, Leah M. ;

Roth, Andrew ;

Rosner, Jamie ;

Shumansky, Karey ;

Kalloger, Steve ;

Senz, Janine ;

Yang, Winnie ;

McConechy, Melissa ;

Melnyk, Nataliya ;

Anglesio, Michael ;

Luk, Margaret T. Y. ;

Tse, Kane ;

Zeng, Thomas ;

Moore, Richard ;

Zhao, Yongjun ;

Marra, Marco A. ;

Gilks, Blake ;

Yip, Stephen ;

Huntsman, David G. ;

McAlpine, Jessica N. ;

Shah, Sohrab P. .

JOURNAL OF PATHOLOGY, 2013, 231 (01) :21-34

[8] Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes [J].

Beaufort, Corine M. ;

Helmijr, Jean C. A. ;

Piskorz, Anna M. ;

Hoogstraat, Marlous ;

Ruigrok-Ritstier, Kirsten ;

Besselink, Nicolle ;

Murtaza, Muhammed ;

van IJcken, Wilfred F. J. ;

Heine, Anouk A. J. ;

Smid, Marcel ;

Koudijs, Marco J. ;

Brenton, James D. ;

Berns, Els M. J. J. ;

Helleman, Jozien .

PLOS ONE, 2014, 9 (09)

[9] Integrated genomic analyses of ovarian carcinoma [J].

Bell, D. ;

Berchuck, A. ;

Birrer, M. ;

Chien, J. ;

Cramer, D. W. ;

Dao, F. ;

Dhir, R. ;

DiSaia, P. ;

Gabra, H. ;

Glenn, P. ;

Godwin, A. K. ;

Gross, J. ;

Hartmann, L. ;

Huang, M. ;

Huntsman, D. G. ;

Iacocca, M. ;

Imielinski, M. ;

Kalloger, S. ;

Karlan, B. Y. ;

Levine, D. A. ;

Mills, G. B. ;

Morrison, C. ;

Mutch, D. ;

Olvera, N. ;

Orsulic, S. ;

Park, K. ;

Petrelli, N. ;

Rabeno, B. ;

Rader, J. S. ;

Sikic, B. I. ;

Smith-McCune, K. ;

Sood, A. K. ;

Bowtell, D. ;

Penny, R. ;

Testa, J. R. ;

Chang, K. ;

Dinh, H. H. ;

Drummond, J. A. ;

Fowler, G. ;

Gunaratne, P. ;

Hawes, A. C. ;

Kovar, C. L. ;

Lewis, L. R. ;

Morgan, M. B. ;

Newsham, I. F. ;

Santibanez, J. ;

Reid, J. G. ;

Trevino, L. R. ;

Wu, Y. -Q. ;

Wang, M. .

NATURE, 2011, 474 (7353) :609-615

[10]

BEREK JS, 1984, OBSTET GYNECOL, V64, P708

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