Chemical synthesis of 7-ethyl-10-hydroxycamptothecin derivative

被引：0
|
作者：
Kuang, Hao [1 ]
Wang, Jisheng [1 ]
Hong, Zhiming [2 ]
Li, Haisong [1 ]
机构：
[1] Beijing Univ Chinese Med, Beijing, Peoples R China
[2] Guangzhou Univ Chinese Med, Shenzhen, Peoples R China
来源：
PRZEMYSL CHEMICZNY | 2024年 / 103卷 / 02期
关键词：
camptothecin; 7-ethyl-10-hydroxy-camptothecin; ethylene glycol; chemical synthesis; click reaction; CANCER; DRUG; NANOPARTICLES; GLUTATHIONE; IRINOTECAN; RESISTANT;
D O I：
10.15199/62.2024.2.6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An 7-Et-10-hydroxycamptothecin (I) derivative was synthesized with a high yield (up to 88%) by nucleophilic substitution by using ethylene glycol as starting material. The OH group was introduced at the C-10 position of camptothecin structure through nucleophilic substitution and an glucose azide was used for the following click reaction.
引用
收藏
页码：262 / 265
页数：4
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