Application of immune checkpoint inhibitors for resectable gastric/gastroesophageal cancer

被引：5
作者：
Lin, Feizhi [1 ]
Chen, Yongming [1 ]
Huang, Bowen [1 ]
Ruan, Shenghang [1 ]
Lin, Jun [1 ]
Chen, Zewei [1 ]
Huang, Chunyu [1 ]
Zhao, Baiwei [1 ]
机构：
[1] Sun Yat Sen Univ, Guangdong Prov Clin Res Ctr Canc, State Key Lab Oncol South China, Canc Ctr, Guangzhou, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷
关键词：
perioperative treatment; gastric cancer; immunotherapy; neoadjuvant therapy; adjuvant therapy; chemotherapy; GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA; RANDOMIZED PHASE-II; GASTRIC-CANCER; OPEN-LABEL; DOUBLE-BLIND; PERIOPERATIVE CHEMOTHERAPY; PLUS CHEMOTHERAPY; TRIAL; OXALIPLATIN; GASTRECTOMY;
D O I：
10.3389/fphar.2024.1391562
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Gastric/gastroesophageal junction (G/GEJ) cancer represents a significant global health challenge. Radical surgery remains the cornerstone of treatment for resectable G/GEJ cancer. Supported by robust evidence from multiple clinical studies, therapeutic approaches, including adjuvant chemotherapy or chemoradiation, and perioperative chemotherapy, are generally recommended to reduce the risk of recurrence and enhance long-term survival outcomes post-surgery. In recent years, immune checkpoint inhibitors (ICIs) have altered the landscape of systemic treatment for advanced or metastatic G/GEJ cancer, becoming the standard first-line therapy for specific patients. Consequently, exploring the efficacy of ICIs in the adjuvant or neoadjuvant setting for resectable G/GEJ cancer is worthwhile. This review summarizes the current advances in the application of ICIs for resectable G/GEJ cancer.
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页数：13
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