Genetic Links between Reproductive Traits and Amino Acid Pairwise Distances of Swine Leukocyte Antigen Alleles among Mating Partners in Microminipigs

被引:0
作者
Ando, Asako [1 ]
Matsubara, Tatsuya [2 ]
Suzuki, Shingo [1 ]
Imaeda, Noriaki [2 ]
Takasu, Masaki [3 ,4 ]
Shigenari, Atsuko [1 ]
Miyamoto, Asuka [1 ]
Ohshima, Shino [1 ]
Kametani, Yoshie [1 ]
Shiina, Takashi [1 ]
Kulski, Jerzy K. [1 ,5 ]
Kitagawa, Hitoshi [2 ,6 ]
机构
[1] Tokai Univ, Dept Mol Life Sci, Div Basic Med Sci & Mol Med, Sch Med, Isehara 2591193, Japan
[2] Gifu Univ, Fac Appl Biol Sci, Joint Dept Vet Med, Gifu 5011193, Japan
[3] Gifu Univ, Inst Adv Study, Gifu 5011193, Japan
[4] Gifu Univ, Ctr One Med Innovat Translat Res Com, Gifu 5011193, Japan
[5] Univ Western Australia, Fac Hlth & Med Sci, Sch Biomed Sci, Crawley, WA 6009, Australia
[6] Okayama Univ Sci, Fac Vet Med, Lab Vet Internal Med, 1-3 Ikoino Oka, Imabari, Ehime 7948555, Japan
关键词
amino acid distance; litter sizes; microminipig; reproductive trait; swine leukocyte antigen; MAJOR HISTOCOMPATIBILITY COMPLEX; CLASS-II HAPLOTYPES; MATE CHOICE; LITTER SIZE; PIG; ASSOCIATION; PATTERNS; HUMANS; BODY; SLA;
D O I
10.3390/ijms25137362
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Previously, we found that a greater dissimilarity in swine leukocyte antigen (SLA) class I and class II alleles between mating partners resulted in increased farrowing rates in a highly inbred population of Microminipigs (MMPs). In this follow-up study, we have analyzed the effects of dissimilarity in SLA alleles between mating partners for seven different reproductive traits, including litter size and the number of stillborn and live or dead weaned piglets. We determined the relationships among reproductive traits within each mating event and the amino acid distances of SLA alleles as markers of diversity between mating partners. Our results indicate that mating partners with greater amino acid pairwise genetic distances in the SLA-1 class I gene or DQB1 class II gene alleles were associated with significantly larger litter sizes and higher numbers of live piglets at birth and weaning. Also, partners with greater pairwise distances in the SLA-2 class I gene alleles exhibited fewer pre-weaning deaths. These findings suggest that the dissimilarity in SLA class I and class II alleles between mating partners may affect not only farrowing rates but also other key reproductive traits such as litter size and improved piglet survival rates. Consequently, SLA alleles could serve as valuable genetic markers for selecting mating partners in breeding programs and for conducting epistatic studies on various reproductive traits in MMPs.
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页数:13
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