Non-coding RNA therapeutics in the treatment of heart failure

被引：3

作者：

Paterek, Aleksandra ^{[1
]}

Zaleska-Kociecka, Marta ^{[2
]}

Surzykiewicz, Mateusz ^{[1
]}

Wojdynska, Zuzanna ^{[2
]}

Leszek, Przemyslaw ^{[2
]}

Maczewski, Michal ^{[1
]}

机构：

[1] Ctr Postgrad Med Educ, Dept Clin Physiol, Marymoncka 99-103, PL-01813 Warsaw, Poland

[2] Natl Inst Cardiol, Heart Failure & Transplantol Dept, Mech Circulatory Support & Transplant Dept, Alpejska 42, PL-04628 Warsaw, Poland

来源：

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY | 2024年 / 10卷 / 04期

关键词：

Non-coding RNA; Heart failure; Therapy; Heart failure with reduced ejection fraction; MicroRNA; ANTISENSE OLIGONUCLEOTIDES; TARGETED DELIVERY; ANIMAL-MODEL; DOUBLE-BLIND; MICRORNAS; REVEALS; ANGIOTENSINOGEN; INTERFERENCE; HYPERTROPHY; SUPPRESSION;

D O I：

10.1093/ehjcvp/pvae027

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Non-coding RNA (ncRNA) therapeutics can target either ncRNAs or conventional messenger RNA, offering both superior pharmacokinetics and selectivity to conventional therapies and addressing new, previously unexplored pathways. Although no ncRNA has yet been approved for the treatment of heart failure, in this review we present five most promising pathways and agents that either are in human clinical trials or offer great promise in the near future.

引用

页码：353 / 360

页数：8

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