A Review of the Evolving Role of Radiotherapy in the Treatment of Neuroendocrine Neoplasms

被引:1
作者
Yit, Ling Fung Nelson [1 ,2 ]
Li, Youquan [1 ,2 ]
机构
[1] Natl Canc Ctr Singapore, Div Radiat Oncol, Singapore, Singapore
[2] Duke NUS Med Sch, Singapore, Singapore
关键词
Image-guided radiation therapy; Intensity-modulated radiotherapy; Stereotactic body radiotherapy; Radiotherapy; Neuroendocrine neoplasms; Neuroendocrine carcinoma; CLINICAL-PRACTICE GUIDELINES; ENETS CONSENSUS GUIDELINES; MERKEL CELL-CARCINOMA; EXTERNAL-BEAM RADIATION; PROGNOSTIC-FACTORS; SYSTEMIC THERAPY; MANAGEMENT; DIAGNOSIS; CANCER; TUMORS;
D O I
10.1159/000538140
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Neuroendocrine neoplasms (NENs) are rare tumours that develop from neuroendocrine cells in various parts of the body. The management of this disease poses a significant challenge because of the heterogeneous clinical presentation and varying degrees of aggressiveness. A multidisciplinary approach is often required in complex clinical situations. Radiotherapy (RT) plays a key role in managing NETs in both curative and palliative settings. Summary: In this review, we summarize and discuss recent developments in the field of advanced RT in early-stage, locally advanced, and metastatic NENs. We highlight limitations in current approaches and discuss future potential treatment strategies for patients with NENs.
引用
收藏
页码:856 / 865
页数:10
相关论文
共 103 条
[81]  
Shah Manisha H, 2021, J Natl Compr Canc Netw, V19, P839, DOI 10.6004/jnccn.2021.0032
[82]  
Shah MH., 2021, J NATL COMPR CANC NE, V19, P28
[83]   Neuroendocrine tumors of genitourinary tract: Recent advances [J].
Shehabeldin, Ahmed N. ;
Ro, Jae Y. .
ANNALS OF DIAGNOSTIC PATHOLOGY, 2019, 42 :48-58
[84]   The NANETS Consensus Guidelines for the Diagnosis and Management of Poorly Differentiated (High-Grade) Extrapulmonary Neuroendocrine Carcinomas [J].
Strosberg, Jonathan R. ;
Coppola, Domenico ;
Klimstra, David S. ;
Phan, Alexandria T. ;
Kulke, Matthew H. ;
Wiseman, Gregory A. ;
Kvols, Larry K. .
PANCREAS, 2010, 39 (06) :799-800
[85]   Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future [J].
Stueven, Anna Kathrin ;
Kayser, Antonin ;
Wetz, Christoph ;
Amthauer, Holger ;
Wree, Alexander ;
Tacke, Frank ;
Wiedenmann, Bertram ;
Roderburg, Christoph ;
Jann, Henning .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (12)
[86]   Primary Neuroendocrine Tumor of the Breast: Current Understanding and Future Perspectives [J].
Sun, Hongna ;
Dai, Shuang ;
Xu, Junnan ;
Liu, Linan ;
Yu, Jiaxing ;
Sun, Tao .
FRONTIERS IN ONCOLOGY, 2022, 12
[87]   Oligometastatic Cancer: Key Concepts and Research Opportunities for 2021 and Beyond [J].
Szturz, Petr ;
Vermorken, Jan B. .
CANCERS, 2021, 13 (11)
[88]  
Taal B G, 2004, Neuroendocrinology, V80 Suppl 1, P3, DOI 10.1159/000080731
[89]  
Tello TL, 2018, J AM ACAD DERMATOL, V78, P445, DOI 10.1016/j.jaad.2017.12.004
[90]   The Role of Radiation Therapy in the Treatment of Medullary Thyroid Cancer [J].
Terezakis, Stephanie A. ;
Lee, Nancy Y. .
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2010, 8 (05) :532-541