The role of ferroptosis in acute kidney injury: mechanisms and potential therapeutic targets

被引：2

作者：

Yu, Yanxin ^{[1
]}

Zhang, Lei ^{[1
]}

Zhang, Die ^{[1
]}

Dai, Qiangfang ^{[1
]}

Hou, Mingzheng ^{[1
]}

Chen, Meini ^{[1
]}

Gao, Feng ^{[1
]}

Liu, Xiao-Long ^{[1
]}

机构：

[1] Yanan Univ, Yanan Small Mol Innovat Drug R&D Engn Res Ctr, Sch Med, Yanan, Peoples R China

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2025年 / 480卷 / 02期

关键词：

Ferroptosis; Acute kidney injury; Regulatory mechanisms; Treatment progress; Models of AKI; REV-ERB-ALPHA; ISCHEMIA-REPERFUSION INJURY; REGULATED CELL-DEATH; ARISTOLOCHIC ACID-I; CRUSH SYNDROME; LIPID-PEROXIDATION; CLINICAL-OUTCOMES; IRON-METABOLISM; EMERGING ROLE; RENAL INJURY;

D O I：

10.1007/s11010-024-05056-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Acute kidney injury (AKI) is one of the most common and severe clinical renal syndromes with high morbidity and mortality. Ferroptosis is a form of programmed cell death (PCD), is characterized by iron overload, reactive oxygen species accumulation, and lipid peroxidation. As ferroptosis has been increasingly studied in recent years, it is closely associated with the pathophysiological process of AKI and provides a target for the treatment of AKI. This review offers a comprehensive overview of the regulatory mechanisms of ferroptosis, summarizes its role in various AKI models, and explores its interaction with other forms of cell death, it also presents research on ferroptosis in AKI progression to other diseases. Additionally, the review highlights methods for detecting and assessing AKI through the lens of ferroptosis and describes potential inhibitors of ferroptosis for AKI treatment. Finally, the review presents a perspective on the future of clinical AKI treatment, aiming to stimulate further research on ferroptosis in AKI.

引用

页码：759 / 784

页数：26

共 343 条

[1] The nephrotoxicity of Aristolochia rotunda L. in rats: Mitochondrion as a target for renal toxicity of Aristolochic acids-containing plants [J].

Abolhassanzadeh, Zohreh ;

Ansari, Simin ;

Lorigooini, Zahra ;

Anjomshoa, Maryam ;

Bijad, Elham ;

Ramezannezhad, Pantea ;

Zarei, Mohammad Hadi .

HELIYON, 2023, 9 (11)

[2] Metabolic Acidosis in Patients with CKD: Epidemiology, Pathogenesis, and Treatment [J].

Adamczak, Marcin ;

Surma, Stanislaw .

KIDNEY DISEASES, 2021, 7 (06) :452-467

[3] Acute Kidney Injury: A Bona Fide Complication of Diabetes [J].

Advani, Andrew .

DIABETES, 2020, 69 (11) :2229-2237

[4] Post-injury Inhibition of Endothelin-1 Dependent Renal Vasoregulation Mitigates Rhabdomyolysis-Induced Acute Kidney Injury [J].

Afolabi, Jeremiah M. ;

Kanthakumar, Praghalathan ;

Williams, Jada D. ;

Kumar, Ravi ;

Soni, Hitesh ;

Adebiyi, Adebowale .

FUNCTION, 2023, 4 (04)

[5] The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death [J].

Ai, Youwei ;

Meng, Yutong ;

Yan, Bo ;

Zhou, Qinyi ;

Wang, Xiaodong .

MOLECULAR CELL, 2024, 84 (01) :170-179

[6] Golgi stress mediates redox imbalance and ferroptosis in human cells [J].

Alborzinia, Named ;

Ignashkova, Tatiana I. ;

Dejure, Francesca R. ;

Gendarme, Mathieu ;

Theobald, Jannick ;

Woelfi, Stefan ;

Lindemann, Ralph K. ;

Reiling, Jan H. .

COMMUNICATIONS BIOLOGY, 2018, 1

[7] Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis [J].

Alli, Abdel A. ;

Desai, Dhruv ;

Elshika, Ahmed ;

Conrad, Marcus ;

Proneth, Bettina ;

Clapp, William ;

Atkinson, Carl ;

Segal, Mark ;

Searcy, Louis A. ;

Denslow, Nancy D. ;

Bolisetty, Subhashini ;

Mehrad, Borna ;

Morel, Laurence ;

Scindia, Yogesh .

CLINICAL IMMUNOLOGY, 2023, 248

[8] NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8 [J].

Anandhan, Annadurai ;

Dodson, Matthew ;

Shakya, Aryatara ;

Chen, Jinjing ;

Liu, Pengfei ;

Wei, Yongyi ;

Tan, Hui ;

Wang, Qian ;

Jiang, Ziyan ;

Yang, Kevin ;

Garcia, Joe G. N. ;

Chambers, Setsuko K. ;

Chapman, Eli ;

Ooi, Aikseng ;

Yang-Hartwich, Yang ;

Stockwell, Brent R. ;

Zhang, Donna D. .

SCIENCE ADVANCES, 2023, 9 (05)

[9] Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice [J].

Angeli, Jose Pedro Friedmann ;

Schneider, Manuela ;

Proneth, Bettina ;

Tyurina, Yulia Y. ;

Tyurin, Vladimir A. ;

Hammond, Victoria J. ;

Herbach, Nadja ;

Aichler, Michaela ;

Walch, Axel ;

Eggenhofer, Elke ;

Basavarajappa, Devaraj ;

Radmark, Olof ;

Kobayashi, Sho ;

Seibt, Tobias ;

Beck, Heike ;

Neff, Frauke ;

Esposito, Irene ;

Wanke, Ruediger ;

Foerster, Heidi ;

Yefremova, Olena ;

Heinrichmeyer, Marc ;

Bornkamm, Georg W. ;

Geissler, Edward K. ;

Thomas, Stephen B. ;

Stockwell, Brent R. ;

O'Donnell, Valerie B. ;

Kagan, Valerian E. ;

Schick, Joel A. ;

Conrad, Marcus .

NATURE CELL BIOLOGY, 2014, 16 (12) :1180-U120

[10] Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE [J].

Anthonymuthu, Tamil S. ;

Kenny, Elizabeth M. ;

Shrivastava, Indira ;

Tyurina, Yulia Y. ;

Hier, Zachary E. ;

Ting, Hsiu-Chi ;

Dar, Haider H. ;

Tyurin, Vladimir A. ;

Nesterova, Anastasia ;

Amoscato, Andrew A. ;

Mikulska-Ruminska, Karolina ;

Rosenbaum, Joel C. ;

Mao, Gaowei ;

Zhao, Jinming ;

Conrad, Marcus ;

Kellum, John A. ;

Wenzel, Sally E. ;

VanDemark, Andrew P. ;

Bahar, Ivet ;

Kagan, Valerian E. ;

Bayir, Hulya .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 140 (51) :17835-17839

← 1 2 3 4 5 6 7 8 9 10 →