Antioxidant properties and thrombogenic evaluation of Copper-Manganese Alloy-Doped hydroxyapatite in comparison to un-doped hydroxyapatite

This research investigates the antioxidant properties and thrombogenic evaluation of a novel biomaterial-copper and manganese doped hydroxyapatite (CuMn-HAP) in comparison to un-doped hydroxyapatite (HAP). The alloy, containing 1 wt% Cu and 2 wt% Mn, introduces advanced functionalities to enhance clinical outcomes. Essential trace elements, Cu and Mn, are strategically incorporated due to their established roles as micronutrients with antioxidant properties. The study employs microstructural investigation, phase and compound formation, changes in absorbance, clotting behaviour of the blood, and antioxidant behaviour. Comprehensive synthesis, characterization, and in vitro evaluation methods reveal the alloy 's potential to mitigate oxidative stress and reduce thrombotic risk. This exploration contributes to biomaterials science, addressing critical issues in implantable materials and promising improved outcomes for regenerative medicine and medical devices.